A longitudinal study of household water, sanitation, and hygiene characteristics and environmental enteropathy markers in children less than 24 months in Iquitos, Peru

Natalie G. Exum, Gwenyth O. Lee, Maribel Paredes Olórtegui, Pablo Peñataro Yori, Mery Siguas Salas, Dixner Rengifo Trigoso, Josh M. Colston, Kellogg J. Schwab, Benjamin J.J. McCormick, Margaret N. Kosek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Poor child gut health, resulting from a lack of access to an improved toilet or clean water, has been proposed as a biological mechanism underlying child stunting and oral vaccine failure. Characteristics related to household sanitation, water use, and hygiene were measured among a birth cohort of 270 children from peri-urban Iquitos Peru. These children had monthly stool samples and urine samples at four time points and serum samples at (2-4) time points analyzed for biomarkers related to intestinal inflammation and permeability. We found that less storage of fecal matter near the household along with a reliable water connection were associated with reduced inflammation, most prominently the fecal biomarker myeloperoxidase (MPO) (no sanitation facility compared with those with an onsite toilet had -0.43 log MPO, 95% confidence interval [CI]: -0.74, -0.13; and households with an intermittent connection versus those with a continuous supply had +0.36 log MPO,95%CI: 0.08, 0.63). These results provide preliminary evidence for the hypothesis that children less than 24 months of age living in unsanitary conditions will have elevated gut inflammation.

Original languageEnglish
Pages (from-to)995-1004
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number4
Early online date12 Feb 2018
DOIs
Publication statusPublished - 2018

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