A longitudinal study of lung function from 1 month to 18 years of age

Steve Turner, Shona Fielding, Dave Mullane, Des W Cox, Jack Goldblatt, Lou Landau, Peter le Souef

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


BACKGROUND: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age.

METHODS: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF(25-75)). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models.

RESULTS: Lung function (maximal flow at functional residual capacity in infants and FEF(25-75) in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8%), flow limitation (mean reduction 17.4%), infant atopy (mean reduction 12.6%) and maternal smoking (mean reduction in lung function 8.1%) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but % lung function increased in boys by a mean of 1%/year compared with girls, in flow-limited individuals by 3.0%/year and by 0.9%/year for those exposed to maternal smoking during pregnancy compared to other cohort members.

CONCLUSIONS: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
Issue number11
Early online date2 Jun 2014
Publication statusPublished - Nov 2014


  • Adolescent
  • Asthma
  • Child
  • Child, Preschool
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Forecasting
  • Humans
  • Infant
  • Infant, Newborn
  • Lung
  • Male
  • Maternal Exposure
  • Pregnancy
  • Respiratory Function Tests
  • Respiratory Physiological Phenomena
  • Respiratory Sounds


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