A longitudinal study of lung function from 1 month to 18 years of age

Steve Turner, Shona Fielding, Dave Mullane, Des W Cox, Jack Goldblatt, Lou Landau, Peter le Souef

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age.

METHODS: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF(25-75)). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models.

RESULTS: Lung function (maximal flow at functional residual capacity in infants and FEF(25-75) in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8%), flow limitation (mean reduction 17.4%), infant atopy (mean reduction 12.6%) and maternal smoking (mean reduction in lung function 8.1%) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but % lung function increased in boys by a mean of 1%/year compared with girls, in flow-limited individuals by 3.0%/year and by 0.9%/year for those exposed to maternal smoking during pregnancy compared to other cohort members.

CONCLUSIONS: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalThorax
Volume69
Issue number11
Early online date2 Jun 2014
DOIs
Publication statusPublished - Nov 2014

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Longitudinal Studies
Lung
Mothers
Asthma
Smoking
Functional Residual Capacity
Pregnancy

Keywords

  • Adolescent
  • Asthma
  • Child
  • Child, Preschool
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Forecasting
  • Humans
  • Infant
  • Infant, Newborn
  • Lung
  • Male
  • Maternal Exposure
  • Pregnancy
  • Respiratory Function Tests
  • Respiratory Physiological Phenomena
  • Respiratory Sounds

Cite this

Turner, S., Fielding, S., Mullane, D., Cox, D. W., Goldblatt, J., Landau, L., & le Souef, P. (2014). A longitudinal study of lung function from 1 month to 18 years of age. Thorax, 69(11), 1015-1020. https://doi.org/10.1136/thoraxjnl-2013-204931

A longitudinal study of lung function from 1 month to 18 years of age. / Turner, Steve; Fielding, Shona; Mullane, Dave; Cox, Des W; Goldblatt, Jack; Landau, Lou; le Souef, Peter.

In: Thorax, Vol. 69, No. 11, 11.2014, p. 1015-1020.

Research output: Contribution to journalArticle

Turner, S, Fielding, S, Mullane, D, Cox, DW, Goldblatt, J, Landau, L & le Souef, P 2014, 'A longitudinal study of lung function from 1 month to 18 years of age', Thorax, vol. 69, no. 11, pp. 1015-1020. https://doi.org/10.1136/thoraxjnl-2013-204931
Turner, Steve ; Fielding, Shona ; Mullane, Dave ; Cox, Des W ; Goldblatt, Jack ; Landau, Lou ; le Souef, Peter. / A longitudinal study of lung function from 1 month to 18 years of age. In: Thorax. 2014 ; Vol. 69, No. 11. pp. 1015-1020.
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abstract = "BACKGROUND: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age.METHODS: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF(25-75)). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models.RESULTS: Lung function (maximal flow at functional residual capacity in infants and FEF(25-75) in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8{\%}), flow limitation (mean reduction 17.4{\%}), infant atopy (mean reduction 12.6{\%}) and maternal smoking (mean reduction in lung function 8.1{\%}) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but {\%} lung function increased in boys by a mean of 1{\%}/year compared with girls, in flow-limited individuals by 3.0{\%}/year and by 0.9{\%}/year for those exposed to maternal smoking during pregnancy compared to other cohort members.CONCLUSIONS: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.",
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T1 - A longitudinal study of lung function from 1 month to 18 years of age

AU - Turner, Steve

AU - Fielding, Shona

AU - Mullane, Dave

AU - Cox, Des W

AU - Goldblatt, Jack

AU - Landau, Lou

AU - le Souef, Peter

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/11

Y1 - 2014/11

N2 - BACKGROUND: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age.METHODS: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF(25-75)). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models.RESULTS: Lung function (maximal flow at functional residual capacity in infants and FEF(25-75) in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8%), flow limitation (mean reduction 17.4%), infant atopy (mean reduction 12.6%) and maternal smoking (mean reduction in lung function 8.1%) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but % lung function increased in boys by a mean of 1%/year compared with girls, in flow-limited individuals by 3.0%/year and by 0.9%/year for those exposed to maternal smoking during pregnancy compared to other cohort members.CONCLUSIONS: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.

AB - BACKGROUND: Our hypothesis was that factors associated with wheeze will be associated with changes in lung function trajectory between 1 month and 18 years of age.METHODS: Measurements of lung function were made in individuals aged 1, 6 and 12 months (V'maxFRC), and also at ages 6, 12 and 18 years (FEF(25-75)). Changes in lung function over time relative to sex, a history of asthma, maternal asthma and other factors were explored using random coefficient models.RESULTS: Lung function (maximal flow at functional residual capacity in infants and FEF(25-75) in children) was determined in 241 individuals at 1 month, 192 at 6 months, 164 at 12 months, 106 at 6 years, 183 at 12 years and 141 at 18 years. In the multivariable model, maternal asthma (mean reduction in lung function 9.8%), flow limitation (mean reduction 17.4%), infant atopy (mean reduction 12.6%) and maternal smoking (mean reduction in lung function 8.1%) were acting independently. When interactions with time were sought, the reduction in lung function associated with maternal asthma and infant atopy were consistent over time, but % lung function increased in boys by a mean of 1%/year compared with girls, in flow-limited individuals by 3.0%/year and by 0.9%/year for those exposed to maternal smoking during pregnancy compared to other cohort members.CONCLUSIONS: Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can 'recover' in some settings.

KW - Adolescent

KW - Asthma

KW - Child

KW - Child, Preschool

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - Forecasting

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Lung

KW - Male

KW - Maternal Exposure

KW - Pregnancy

KW - Respiratory Function Tests

KW - Respiratory Physiological Phenomena

KW - Respiratory Sounds

U2 - 10.1136/thoraxjnl-2013-204931

DO - 10.1136/thoraxjnl-2013-204931

M3 - Article

VL - 69

SP - 1015

EP - 1020

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 11

ER -