A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C and follistatin during pregnancy

P A Fowler, L W Evans, N P Groome, A Templeton, P G Knight

Research output: Contribution to journalArticle

Abstract

Maternal serum concentrations of inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C-related inhibin forms, total follistatin, steroids and gonadotrophins were measured longitudinally in six normal singleton pregnancies. Maternal venous blood was collected randomly during a spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11, 16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the early puerperium, Steroid and gonadotrophin profiles conformed to previous reports. While at week 5 of gestation inhibin-A, activin-A and follistatin concentrations were similar to those at the follicular phase, all three increased progressively (P < 0.001) to maximal concentrations in week 36: similar to 48-fold (3740 +/- 1349 ng inhibin-A/ml), similar to 22-fold (6109 +/- 1443 ng activin-A/ml) and similar to 10-fold (3563 +/- 418 ng follistatin/ml) higher Pro-alpha C concentrations reached a maximum in weeks 5 (similar to 5-fold, P < 0.001) and 36 (1027 +/- 174 pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was undetectable (<12 pg/ml) between week 5-16 of gestation hut increased slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was undetectable throughout pregnancy. Post-partum concentrations of inhibin-A (41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml), pro-alpha C (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were substantially lower than at week 36 of gestation. The activin-A:follistatin ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more free activin-A is available in the maternal circulation during late pregnancy.

Original languageEnglish
Pages (from-to)3530-3536
Number of pages7
JournalHuman Reproduction Update
Volume13
Publication statusPublished - 1998

Keywords

  • activin
  • follistatin
  • gestation
  • inhibin
  • steroids
  • LINKED-IMMUNOSORBENT-ASSAY
  • HUMAN FOLLICULAR-FLUID
  • HUMAN MENSTRUAL-CYCLE
  • HUMAN-PLACENTA
  • GESTATIONAL DISEASES
  • DIMERIC INHIBIN
  • FORMS
  • GONADOTROPIN
  • SECRETION
  • PROTEINS

Cite this

A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C and follistatin during pregnancy. / Fowler, P A ; Evans, L W ; Groome, N P ; Templeton, A ; Knight, P G .

In: Human Reproduction Update, Vol. 13, 1998, p. 3530-3536.

Research output: Contribution to journalArticle

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abstract = "Maternal serum concentrations of inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C-related inhibin forms, total follistatin, steroids and gonadotrophins were measured longitudinally in six normal singleton pregnancies. Maternal venous blood was collected randomly during a spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11, 16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the early puerperium, Steroid and gonadotrophin profiles conformed to previous reports. While at week 5 of gestation inhibin-A, activin-A and follistatin concentrations were similar to those at the follicular phase, all three increased progressively (P < 0.001) to maximal concentrations in week 36: similar to 48-fold (3740 +/- 1349 ng inhibin-A/ml), similar to 22-fold (6109 +/- 1443 ng activin-A/ml) and similar to 10-fold (3563 +/- 418 ng follistatin/ml) higher Pro-alpha C concentrations reached a maximum in weeks 5 (similar to 5-fold, P < 0.001) and 36 (1027 +/- 174 pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was undetectable (<12 pg/ml) between week 5-16 of gestation hut increased slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was undetectable throughout pregnancy. Post-partum concentrations of inhibin-A (41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml), pro-alpha C (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were substantially lower than at week 36 of gestation. The activin-A:follistatin ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more free activin-A is available in the maternal circulation during late pregnancy.",
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T1 - A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C and follistatin during pregnancy

AU - Fowler, P A

AU - Evans, L W

AU - Groome, N P

AU - Templeton, A

AU - Knight, P G

PY - 1998

Y1 - 1998

N2 - Maternal serum concentrations of inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C-related inhibin forms, total follistatin, steroids and gonadotrophins were measured longitudinally in six normal singleton pregnancies. Maternal venous blood was collected randomly during a spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11, 16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the early puerperium, Steroid and gonadotrophin profiles conformed to previous reports. While at week 5 of gestation inhibin-A, activin-A and follistatin concentrations were similar to those at the follicular phase, all three increased progressively (P < 0.001) to maximal concentrations in week 36: similar to 48-fold (3740 +/- 1349 ng inhibin-A/ml), similar to 22-fold (6109 +/- 1443 ng activin-A/ml) and similar to 10-fold (3563 +/- 418 ng follistatin/ml) higher Pro-alpha C concentrations reached a maximum in weeks 5 (similar to 5-fold, P < 0.001) and 36 (1027 +/- 174 pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was undetectable (<12 pg/ml) between week 5-16 of gestation hut increased slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was undetectable throughout pregnancy. Post-partum concentrations of inhibin-A (41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml), pro-alpha C (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were substantially lower than at week 36 of gestation. The activin-A:follistatin ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more free activin-A is available in the maternal circulation during late pregnancy.

AB - Maternal serum concentrations of inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C-related inhibin forms, total follistatin, steroids and gonadotrophins were measured longitudinally in six normal singleton pregnancies. Maternal venous blood was collected randomly during a spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11, 16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the early puerperium, Steroid and gonadotrophin profiles conformed to previous reports. While at week 5 of gestation inhibin-A, activin-A and follistatin concentrations were similar to those at the follicular phase, all three increased progressively (P < 0.001) to maximal concentrations in week 36: similar to 48-fold (3740 +/- 1349 ng inhibin-A/ml), similar to 22-fold (6109 +/- 1443 ng activin-A/ml) and similar to 10-fold (3563 +/- 418 ng follistatin/ml) higher Pro-alpha C concentrations reached a maximum in weeks 5 (similar to 5-fold, P < 0.001) and 36 (1027 +/- 174 pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was undetectable (<12 pg/ml) between week 5-16 of gestation hut increased slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was undetectable throughout pregnancy. Post-partum concentrations of inhibin-A (41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml), pro-alpha C (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were substantially lower than at week 36 of gestation. The activin-A:follistatin ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more free activin-A is available in the maternal circulation during late pregnancy.

KW - activin

KW - follistatin

KW - gestation

KW - inhibin

KW - steroids

KW - LINKED-IMMUNOSORBENT-ASSAY

KW - HUMAN FOLLICULAR-FLUID

KW - HUMAN MENSTRUAL-CYCLE

KW - HUMAN-PLACENTA

KW - GESTATIONAL DISEASES

KW - DIMERIC INHIBIN

KW - FORMS

KW - GONADOTROPIN

KW - SECRETION

KW - PROTEINS

M3 - Article

VL - 13

SP - 3530

EP - 3536

JO - Human Reproduction Update

JF - Human Reproduction Update

SN - 1355-4786

ER -