A mathematical model of response of cells to radiation

M. Richard; K. J. Kirkby; R. P. Webb; N. F. Kirkby

doi:10.1016/j.nimb.2006.11.077

A mathematical model of response of cells to radiation

M. Richard, K. J. Kirkby, R. P. Webb, N. F. Kirkby^*

^*Corresponding author for this work

University of Surrey

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation. (c) 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	18-22
Number of pages	5
Journal	Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
Volume	255
Issue number	1
DOIs	https://doi.org/10.1016/j.nimb.2006.11.077
Publication status	Published - Feb 2007
Event	8th International Conference on Computer Simulation of Radiation Effects in Solids - Richland, United Kingdom Duration: 18 Jun 2006 → 23 Jun 2006

Keywords

computer simulation
X-rays irradiation
bystander effect
low dose hyper radio-sensitivity
GLIOMA

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10.1016/j.nimb.2006.11.077

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title = "A mathematical model of response of cells to radiation",

abstract = "Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation. (c) 2006 Elsevier B.V. All rights reserved.",

keywords = "computer simulation, X-rays irradiation, bystander effect, low dose hyper radio-sensitivity, GLIOMA",

author = "M. Richard and Kirkby, {K. J.} and Webb, {R. P.} and Kirkby, {N. F.}",

year = "2007",

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doi = "10.1016/j.nimb.2006.11.077",

language = "English",

volume = "255",

pages = "18--22",

journal = "Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "Elsevier",

number = "1",

note = "8th International Conference on Computer Simulation of Radiation Effects in Solids ; Conference date: 18-06-2006 Through 23-06-2006",

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AU - Richard, M.

AU - Kirkby, K. J.

AU - Webb, R. P.

AU - Kirkby, N. F.

PY - 2007/2

Y1 - 2007/2

N2 - Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation. (c) 2006 Elsevier B.V. All rights reserved.

AB - Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation. (c) 2006 Elsevier B.V. All rights reserved.

KW - computer simulation

KW - X-rays irradiation

KW - bystander effect

KW - low dose hyper radio-sensitivity

KW - GLIOMA

U2 - 10.1016/j.nimb.2006.11.077

DO - 10.1016/j.nimb.2006.11.077

M3 - Article

SN - 0168-583X

VL - 255

SP - 18

EP - 22

JO - Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms

JF - Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms

IS - 1

T2 - 8th International Conference on Computer Simulation of Radiation Effects in Solids

Y2 - 18 June 2006 through 23 June 2006

ER -

A mathematical model of response of cells to radiation

Abstract

Keywords

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