A mathematical model of response of cells to radiation

M. Richard, K. J. Kirkby, R. P. Webb, N. F. Kirkby*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation. (c) 2006 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)18-22
    Number of pages5
    JournalNuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
    Volume255
    Issue number1
    DOIs
    Publication statusPublished - Feb 2007
    Event8th International Conference on Computer Simulation of Radiation Effects in Solids - Richland, United Kingdom
    Duration: 18 Jun 200623 Jun 2006

    Keywords

    • computer simulation
    • X-rays irradiation
    • bystander effect
    • low dose hyper radio-sensitivity
    • GLIOMA

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