A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

Claudiu V. Giuraniuc; Shabana  Zain; Shahmama Ghafoor; Stefan Hoppler

doi:10.1016/j.jtbi.2022.111239

A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

Claudiu V. Giuraniuc^* (Corresponding Author), Shabana Zain, Shahmama Ghafoor, Stefan Hoppler

^*Corresponding author for this work

University of Aberdeen

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Abstract

There are two phases of Wnt signalling in early vertebrate embryogenesis: very
early, maternal Wnt signalling promotes dorsal development, and slightly later,
zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the
direct Wnt target genes, with at least five classes. Here in order to test the
logic and the dynamics of a new Gene Regulatory Network model suggested
by these discoveries we use mathematical modelling based on ordinary differential equations (ODEs). Our mathematical modelling of this Gene Regulatory
Network reveals that a simplified model, with one ”super-gene” for each class
is sufficient to a large extent to describe the regulatory behaviour previously
observed experimentally.

Original language	English
Article number	111239
Number of pages	7
Journal	Journal of Theoretical Biology
Volume	551-552
Early online date	24 Aug 2022
DOIs	https://doi.org/10.1016/j.jtbi.2022.111239
Publication status	Published - 7 Nov 2022

Bibliographical note

Acknowledegements
We would like to express our gratitude to Dr Yasushi Saka for training and encouragement. Funding was received from the BHF (RG/18/8/33673 to CVG and SH) and BBSRC (BB/N021924/1; BB/M001695/1; BB/S018190/1 to SH). S.H. was a Royal Society/Leverhulme Trust Senior Research Fellow (SRF\R1\191017).

Data Availability Statement

Supplementary material related to this article can be found online at https://doi.org/10.1016/j.jtbi.2022.111239.

Keywords

WNT signalling
β-catenin
Xenopus

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Cite this

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A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

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