A meta-analytic review of verbal fluency deficits in Huntington's disease

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.

Original languageEnglish
Pages (from-to)243-252
Number of pages9
JournalNeuropsychology
Volume19
DOIs
Publication statusPublished - 2005

Keywords

  • executive
  • Huntington's
  • meta-analysis
  • SUBCORTICAL DEMENTIA
  • PARKINSONS-DISEASE
  • PERFORMANCE
  • ALZHEIMERS
  • MEMORY
  • IMPAIRMENT
  • PATHOLOGY
  • GENE

Cite this

A meta-analytic review of verbal fluency deficits in Huntington's disease. / Henry, J. D.; Crawford, John Robertson; Phillips, Louise Helen.

In: Neuropsychology, Vol. 19, 2005, p. 243-252.

Research output: Contribution to journalArticle

@article{26cf7f305ac04b0aa266d54b93351c5b,
title = "A meta-analytic review of verbal fluency deficits in Huntington's disease",
abstract = "A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.",
keywords = "executive, Huntington's, meta-analysis, SUBCORTICAL DEMENTIA, PARKINSONS-DISEASE, PERFORMANCE, ALZHEIMERS, MEMORY, IMPAIRMENT, PATHOLOGY, GENE",
author = "Henry, {J. D.} and Crawford, {John Robertson} and Phillips, {Louise Helen}",
year = "2005",
doi = "10.1037/0894-4105.19.2.243",
language = "English",
volume = "19",
pages = "243--252",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association Inc.",

}

TY - JOUR

T1 - A meta-analytic review of verbal fluency deficits in Huntington's disease

AU - Henry, J. D.

AU - Crawford, John Robertson

AU - Phillips, Louise Helen

PY - 2005

Y1 - 2005

N2 - A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.

AB - A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.

KW - executive

KW - Huntington's

KW - meta-analysis

KW - SUBCORTICAL DEMENTIA

KW - PARKINSONS-DISEASE

KW - PERFORMANCE

KW - ALZHEIMERS

KW - MEMORY

KW - IMPAIRMENT

KW - PATHOLOGY

KW - GENE

U2 - 10.1037/0894-4105.19.2.243

DO - 10.1037/0894-4105.19.2.243

M3 - Article

VL - 19

SP - 243

EP - 252

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

ER -