A meta-analytic review of verbal fluency deficits in Huntington's disease

J. D. Henry; John Robertson Crawford; Louise Helen Phillips

doi:10.1037/0894-4105.19.2.243

A meta-analytic review of verbal fluency deficits in Huntington's disease

J. D. Henry, John Robertson Crawford, Louise Helen Phillips

Psychology

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.

Original language	English
Pages (from-to)	243-252
Number of pages	9
Journal	Neuropsychology
Volume	19
DOIs	https://doi.org/10.1037/0894-4105.19.2.243
Publication status	Published - 2005

Keywords

executive
Huntington's
meta-analysis
SUBCORTICAL DEMENTIA
PARKINSONS-DISEASE
PERFORMANCE
ALZHEIMERS
MEMORY
IMPAIRMENT
PATHOLOGY
GENE

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abstract = "A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs = .71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.",

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A meta-analytic review of verbal fluency deficits in Huntington's disease

Abstract

Keywords

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