A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner

Gabriella Aviello, Sylvie Amu, Sean P Saunders, Padraic G Fallon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Inflammatory bowel disease is an urgent public health problem with a high incidence in developed countries. Alterations of lifestyle or dietary interventions may attenuate the disease progression and increase the efficacy of current therapies. Here we tested the effect of chronic supplementation with a mineral extract from red marine algae - rich in calcium (34%), magnesium, phosphorus, selenium and other trace minerals - in a clinically relevant model of spontaneous enterocolitis, interleukin (IL)-10(-/-) mice. The mineral extract was administered in the drinking water of Il10(-/-) mice on C57BL/6 J and BALB/c strain backgrounds for 25 weeks commencing from 3 to 4 weeks of age. The mineral extract ameliorated the spontaneous development of colitis and severity of disease in Il10(-/-) mice on a C57BL/6 J background. Mineral extract-treated Il10(-/-) C57BL/6 J strain mice had significantly reduced mortality, circulating levels of serum Amyloid A and reduced colonic tissue damage. In contrast, comparable treatment of Il10(-/-) mice on a BALB/c background with the mineral extract did not alter the course of colitis. These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild-moderate colitis in Il10(-/-) mice on a C57BL/6 J, but does not attenuate more moderate-severe colitis in BALB/c strain animals.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalPhytotherapy Research
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2014

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Rhodophyta
Colitis
Interleukin-10
Minerals
Enterocolitis
Serum Amyloid A Protein
Military Personnel
Trace Elements
Selenium
Inbred C57BL Mouse
Inflammatory Bowel Diseases
Developed Countries
Drinking Water
Phosphorus
Magnesium
Disease Progression
Life Style
Public Health
Calcium
Mortality

Keywords

  • Animals
  • Calcium
  • Colon
  • Cytokines
  • Dietary Supplements
  • Disease Models, Animal
  • Enterocolitis
  • Female
  • Interleukin-10
  • Magnesium
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Minerals
  • Peroxidase
  • Phosphorus
  • Rhodophyta
  • Selenium
  • Serum Amyloid A Protein
  • Species Specificity
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner. / Aviello, Gabriella; Amu, Sylvie; Saunders, Sean P; Fallon, Padraic G.

In: Phytotherapy Research, Vol. 28, No. 2, 02.2014, p. 300-304.

Research output: Contribution to journalArticle

Aviello, Gabriella ; Amu, Sylvie ; Saunders, Sean P ; Fallon, Padraic G. / A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner. In: Phytotherapy Research. 2014 ; Vol. 28, No. 2. pp. 300-304.
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AB - Inflammatory bowel disease is an urgent public health problem with a high incidence in developed countries. Alterations of lifestyle or dietary interventions may attenuate the disease progression and increase the efficacy of current therapies. Here we tested the effect of chronic supplementation with a mineral extract from red marine algae - rich in calcium (34%), magnesium, phosphorus, selenium and other trace minerals - in a clinically relevant model of spontaneous enterocolitis, interleukin (IL)-10(-/-) mice. The mineral extract was administered in the drinking water of Il10(-/-) mice on C57BL/6 J and BALB/c strain backgrounds for 25 weeks commencing from 3 to 4 weeks of age. The mineral extract ameliorated the spontaneous development of colitis and severity of disease in Il10(-/-) mice on a C57BL/6 J background. Mineral extract-treated Il10(-/-) C57BL/6 J strain mice had significantly reduced mortality, circulating levels of serum Amyloid A and reduced colonic tissue damage. In contrast, comparable treatment of Il10(-/-) mice on a BALB/c background with the mineral extract did not alter the course of colitis. These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild-moderate colitis in Il10(-/-) mice on a C57BL/6 J, but does not attenuate more moderate-severe colitis in BALB/c strain animals.

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