A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Andrew Schrepf, Chelsea M. Kaplan, Eric Ichesco, Tony Larkin, Steven Harte, Richard E. Harris, Alison D. Murray, Gordon D. Waiter, Daniel J. Clauw, Neil Basu

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Abstract

It is unknown how chronic inflammation impacts the brain. Here, we examined whether higher levels of peripheral inflammation were associated with brain connectivity and structure in 54 rheumatoid arthritis patients using functional and structural MRI. We show that higher levels of inflammation are associated with more positive connections between the inferior parietal lobule (IPL), medial prefrontal cortex, and multiple brain networks, as well as reduced IPL grey matter, and that these patterns of connectivity predicted fatigue, pain and cognitive dysfunction. At a second scan 6 months later, some of the same patterns of connectivity were again associated with higher peripheral inflammation. A graph theoretical analysis of whole-brain functional connectivity revealed a pattern of connections spanning 49 regions, including the IPL and medial frontal cortex, that are associated with peripheral inflammation. These regions may play a critical role in transducing peripheral inflammatory signals to the central changes seen in rheumatoid arthritis.
Original languageEnglish
Article number2243
Pages (from-to)1-11
Number of pages11
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 8 Jun 2018

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arthritis
Magnetic resonance imaging
Parietal Lobe
brain
Brain
Rheumatoid Arthritis
Inflammation
cortexes
pain
Frontal Lobe
Encephalitis
Prefrontal Cortex
Fatigue
Magnetic Resonance Imaging
Fatigue of materials
Pain

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Schrepf, A., Kaplan, C. M., Ichesco, E., Larkin, T., Harte, S., Harris, R. E., ... Basu, N. (2018). A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. Nature Communications, 9, 1-11. [2243]. https://doi.org/10.1038/s41467-018-04648-0

A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. / Schrepf, Andrew; Kaplan, Chelsea M.; Ichesco, Eric; Larkin, Tony; Harte, Steven; Harris, Richard E.; Murray, Alison D.; Waiter, Gordon D.; Clauw, Daniel J.; Basu, Neil.

In: Nature Communications, Vol. 9, 2243, 08.06.2018, p. 1-11.

Research output: Contribution to journalArticle

Schrepf, A, Kaplan, CM, Ichesco, E, Larkin, T, Harte, S, Harris, RE, Murray, AD, Waiter, GD, Clauw, DJ & Basu, N 2018, 'A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis', Nature Communications, vol. 9, 2243, pp. 1-11. https://doi.org/10.1038/s41467-018-04648-0
Schrepf, Andrew ; Kaplan, Chelsea M. ; Ichesco, Eric ; Larkin, Tony ; Harte, Steven ; Harris, Richard E. ; Murray, Alison D. ; Waiter, Gordon D. ; Clauw, Daniel J. ; Basu, Neil. / A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. In: Nature Communications. 2018 ; Vol. 9. pp. 1-11.
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