A multinational observational study identifying primary care patients at risk of overestimation of asthma control

Vicky Kritikos* (Corresponding Author), David Price, Alberto Papi, Antonio Infantino, Bjorn Ställberg, Dermot Ryan, Federico Lavorini, Henry Chrystyn, John Haughney, Karin Lisspers, Kevin Gruffydd-Jones, Miguel Román Rodríguez, Svein Høegh Henrichsen, Thys van der Molen, Victoria Carter, Sinthia Bosnic-Anticevich

*Corresponding author for this work

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Abstract

Factors related to the discrepancy between patient-perceived and actual disease control remain unclear. Identifying patients at risk of overestimation of asthma control remains elusive. This study aimed to (i) investigate the relationship between patient-reported and actual level of asthma control (ii), compare the characteristics between patients who believe their asthma is well controlled that accurately report 'well-controlled' asthma with those that do not, and (iii) identify factors associated with inaccurately reported 'well-controlled' asthma. A historical, multinational, cross-sectional study using data from the iHARP (initiative Helping Asthma in Real-life Patients) review service for adults with asthma prescribed fixed-dose combination therapy. Data from 4274 patients were analysed. A major discrepancy between patient-reported and Global Initiative for Asthma defined asthma control was detected; 71.1% of patients who reported 'well-controlled' asthma were inaccurate in their perception despite receiving regular maintenance therapy. Significant differences were noted in age, gender, body mass index, education level, medication use, side effects, attitudes to preventer inhaler use, inhaler technique review and respiratory specialist review between patients who accurately reported 'well-controlled' asthma and those who did not. Independent risk factors associated with inaccurately reported 'well-controlled' asthma were: having taken a maximum of 5-12 puffs or more of reliever inhaler on at least one day within the previous 4 weeks; being female; having seen a respiratory specialist more than a year ago (rather than in the previous year); and having required oral corticosteroids for worsening asthma in the previous year. The study highlighted the significant hidden burden associated with under-recognition of poor asthma control, on the part of the patient and the need for targeted interventions designed to address the continuing discrepancy between perceived and actual disease control.

Original languageEnglish
Article number43
Number of pages9
Journalnpj Primary Care Respiratory Medicine
Volume29
DOIs
Publication statusPublished - 5 Dec 2019

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Observational Studies
Primary Health Care
Asthma
Nebulizers and Vaporizers
Adrenal Cortex Hormones
Body Mass Index
Cross-Sectional Studies
Education

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A multinational observational study identifying primary care patients at risk of overestimation of asthma control. / Kritikos, Vicky (Corresponding Author); Price, David; Papi, Alberto; Infantino, Antonio; Ställberg, Bjorn; Ryan, Dermot; Lavorini, Federico; Chrystyn, Henry; Haughney, John; Lisspers, Karin; Gruffydd-Jones, Kevin; Román Rodríguez, Miguel; Høegh Henrichsen, Svein; van der Molen, Thys; Carter, Victoria; Bosnic-Anticevich, Sinthia.

In: npj Primary Care Respiratory Medicine, Vol. 29, 43, 05.12.2019.

Research output: Contribution to journalArticle

Kritikos, V, Price, D, Papi, A, Infantino, A, Ställberg, B, Ryan, D, Lavorini, F, Chrystyn, H, Haughney, J, Lisspers, K, Gruffydd-Jones, K, Román Rodríguez, M, Høegh Henrichsen, S, van der Molen, T, Carter, V & Bosnic-Anticevich, S 2019, 'A multinational observational study identifying primary care patients at risk of overestimation of asthma control', npj Primary Care Respiratory Medicine, vol. 29, 43. https://doi.org/10.1038/s41533-019-0156-4
Kritikos, Vicky ; Price, David ; Papi, Alberto ; Infantino, Antonio ; Ställberg, Bjorn ; Ryan, Dermot ; Lavorini, Federico ; Chrystyn, Henry ; Haughney, John ; Lisspers, Karin ; Gruffydd-Jones, Kevin ; Román Rodríguez, Miguel ; Høegh Henrichsen, Svein ; van der Molen, Thys ; Carter, Victoria ; Bosnic-Anticevich, Sinthia. / A multinational observational study identifying primary care patients at risk of overestimation of asthma control. In: npj Primary Care Respiratory Medicine. 2019 ; Vol. 29.
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