A neglected epidemic: fungal infections in HIV/AIDS

Darius Armstrong-James, Graeme Meintjes, Gordon D Brown

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths annually from IFIs, accounting for 50% of all AIDS-related death. A historic failure to focus efforts on the IFIs that kill so many HIV patients has led to fundamental flaws in the management of advanced HIV infection. This review, based on the EMBO AIDS-Related Mycoses Workshop in Cape Town in July 2013, summarizes the current state of the-art in AIDS-related mycoses, and the key action points required to improve outcomes from these devastating infections.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalTrends in Microbiology
Volume22
Issue number3
Early online date13 Feb 2014
DOIs
Publication statusPublished - Mar 2014

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Keywords

  • HIV
  • fungal infection
  • immunity
  • AIDS
  • mycoses

Cite this

Armstrong-James, D., Meintjes, G., & Brown, G. D. (2014). A neglected epidemic: fungal infections in HIV/AIDS. Trends in Microbiology, 22(3), 120-127. https://doi.org/10.1016/j.tim.2014.01.001