A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Daniel Sorensen, Amanda Sackett, Daniel J Urban, Jennifer Maier, Neil Vargesson, Karen E Sears (Corresponding Author)

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Downloads (Pure)

Abstract

From 1957 to 1962, thalidomide caused birth defects in >10,000 children. While the drug was pulled from the market, thalidomide is currently prescribed to treat conditions including leprosy. As a result, a new generation of babies with thalidomide defects is being born in the developing world. This represents a serious problem, as the mechanisms by which thalidomide disrupts development remain unresolved. This lack of resolution is due, in part, to the absence of an appropriate mammalian model for thalidomide teratogenesis. We test the hypothesis that opossum (Monodelphis domestica) is well suited to model human thalidomide defects. Results suggest that opossum embryos exposed to thalidomide display a range of phenotypes (e.g., heart, craniofacial, limb defects) and penetrance similar to humans. Furthermore, all opossums with thalidomide defects exhibit vascular disruptions. Results therefore support the hypotheses that opossums make a good mammalian model for thalidomide teratogenesis, and that thalidomide can severely disrupt angiogenesis in mammals.
Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalReproductive Toxicology
Volume70
Early online date24 Jan 2017
DOIs
Publication statusPublished - Jun 2017

Fingerprint

Monodelphis
Teratogenesis
Thalidomide
Opossums
Defects
Mammals
Penetrance
Leprosy
Blood Vessels
Embryonic Structures
Extremities
Phenotype
Pharmaceutical Preparations

Keywords

  • teratogen
  • congenital birth defects
  • limb
  • angiogenesis

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A new mammalian model system for thalidomide teratogenesis : Monodelphis domestica. / Sorensen, Daniel ; Sackett, Amanda; Urban, Daniel J ; Maier, Jennifer ; Vargesson, Neil; Sears, Karen E (Corresponding Author).

In: Reproductive Toxicology, Vol. 70, 06.2017, p. 126-132.

Research output: Contribution to journalArticle

Sorensen, Daniel ; Sackett, Amanda ; Urban, Daniel J ; Maier, Jennifer ; Vargesson, Neil ; Sears, Karen E . / A new mammalian model system for thalidomide teratogenesis : Monodelphis domestica. In: Reproductive Toxicology. 2017 ; Vol. 70. pp. 126-132.
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