A New Method for Investigating Osteoarthritis using Fast Field Cycling Nuclear Magnetic Resonance

Lionel Broche, James Ross* (Corresponding Author), Brett Kennedy, Campbell MacEachern, David Lurie, George P. Ashcroft

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Human articular hyaline cartilage is composed of a dense extracellular matrix (ECM) made up of 70% water and 30% protein. The major protein components are type II collagen and proteoglycans, with other non-collagenous proteins present in small amounts. All are regenerated slowly but continuously by chondrocyte cells through the structure [1] and it is the combination of proteoglycans held within the overall collagen structure that combines to hold water in the ECM, which is essential in the maintenance of its unique mechanical properties. The interactions between proteoglycans and collagen are elusive but known to be of electrostatic nature [2].
Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalPhysica Medica
Volume88
Early online date7 Jul 2021
DOIs
Publication statusE-pub ahead of print - 7 Jul 2021

Keywords

  • Fast field-cycling NMR
  • Human hyaline cartilage
  • osteoarthritis
  • T1 dispersion
  • Quadrupolar peaks
  • protein interactions

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