A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activ-ity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC values of 7.0 and 2.7 µg/mL, respectively, whereas 1 was inactive.
|Number of pages||5|
|Journal||Zeitschrift für Naturforschung - C|
|Publication status||Published - Jun 2009|
Aly, A. H., Debbab, A., Edrada-Ebel, R., Wray, V., Müller, W. E. G., Lin, W., ... Proksch, P. (2009). A new tetrahydrofuran derivative from the Endophytic Fungus Chaetomium sp. isolated from Otanthus maritimus. Zeitschrift für Naturforschung - C, 64(5-6), 350-354.