A novel fast split-echo multi-shot diffusion-weighted MRI method using navigator echoes

C F M Williams, T W Redpath, D G Norris

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Difficulties in obtaining diffusion-weighted images of acceptable quality using conventional hardware and in a reasonable time have hindered the clinical application of diffusion-weighted magnetic resonance imaging (DWI), Diffusion-weighted fast spin-echo (FSE) sequences offer the possibility of fast DWI on standard hardware without the susceptibility problems associated with echoplanar imaging. However, motion in the presence of diffusion-sensitizing gradients can prevent fulfilment of the Meiboom Gill phase condition, leading to destructive interference between echo components and consequent signal losses. A recently proposed single-shot FSE sequence employed split-echo acquisition to address this problem. However, in a segmented FSE sequence, phase errors differ between successive echo trains, causing "ghosting" in the diffusion-weighted images that are not eliminated by split-echo acquistion alone. A DWI technique is presented that combines split-echo acquisition with navigator echo phase correction in a segmented FSE sequence. It is shown to be suitable for diffusion measurements in vivo using standard hardware. (C) 1999 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)734-742
Number of pages9
JournalMagnetic Resonance in Medicine
Volume41
Publication statusPublished - 1999

Keywords

  • MRI
  • fast spin-echo
  • diffusion
  • navigator echo
  • FAST SPIN-ECHO
  • HUMAN BRAIN
  • STIMULATED ECHOES
  • SELF-DIFFUSION
  • SYSTEM
  • COEFFICIENTS
  • ARTIFACTS
  • SEQUENCES
  • MOTION
  • IMAGES

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