A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Xiaodong Zeng, Ziyang Chen, Lin Tang, Han Yang, Nan Liu, Hui Zhou, Yang Li, Junzhu Wu, Zixin Deng, Yi Yu, Hai Deng (Corresponding Author), Xuechuan Hong (Corresponding Author), Yuling Xiao (Corresponding Author)

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

Original languageEnglish
Pages (from-to)2541-2544
Number of pages4
JournalChemical Communications
Volume55
Issue number17
Early online date30 Jan 2019
DOIs
Publication statusPublished - 28 Feb 2019

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Liver
Tumors
Infrared radiation
Imaging techniques
Fibrin
Fibronectins
Pharmaceutical Preparations

Cite this

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection. / Zeng, Xiaodong; Chen, Ziyang; Tang, Lin; Yang, Han; Liu, Nan; Zhou, Hui; Li, Yang; Wu, Junzhu; Deng, Zixin; Yu, Yi ; Deng, Hai (Corresponding Author); Hong, Xuechuan (Corresponding Author); Xiao, Yuling (Corresponding Author).

In: Chemical Communications, Vol. 55, No. 17, 28.02.2019, p. 2541-2544.

Research output: Contribution to journalArticle

Zeng, X, Chen, Z, Tang, L, Yang, H, Liu, N, Zhou, H, Li, Y, Wu, J, Deng, Z, Yu, Y, Deng, H, Hong, X & Xiao, Y 2019, 'A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection', Chemical Communications, vol. 55, no. 17, pp. 2541-2544. https://doi.org/10.1039/c8cc10286d
Zeng, Xiaodong ; Chen, Ziyang ; Tang, Lin ; Yang, Han ; Liu, Nan ; Zhou, Hui ; Li, Yang ; Wu, Junzhu ; Deng, Zixin ; Yu, Yi ; Deng, Hai ; Hong, Xuechuan ; Xiao, Yuling. / A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection. In: Chemical Communications. 2019 ; Vol. 55, No. 17. pp. 2541-2544.
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