A novel pathway for exotoxin delivery by an intracellular pathogen

Stefania Spanò, Jorge E Galán

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.
Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalCurrent Opinion in Microbiology
Volume11
Issue number1
Early online date20 Feb 2008
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Exotoxins
Bacterial Proteins

Keywords

  • animals
  • bacterial toxins
  • exotoxins
  • humans
  • models, biological
  • Salmonella typhi

Cite this

A novel pathway for exotoxin delivery by an intracellular pathogen. / Spanò, Stefania; Galán, Jorge E.

In: Current Opinion in Microbiology, Vol. 11, No. 1, 02.2008, p. 15-20.

Research output: Contribution to journalArticle

Spanò, Stefania ; Galán, Jorge E. / A novel pathway for exotoxin delivery by an intracellular pathogen. In: Current Opinion in Microbiology. 2008 ; Vol. 11, No. 1. pp. 15-20.
@article{47b53d6dd2fe486d98f344eb2821a7e6,
title = "A novel pathway for exotoxin delivery by an intracellular pathogen",
abstract = "Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.",
keywords = "animals, bacterial toxins, exotoxins, humans, models, biological, Salmonella typhi",
author = "Stefania Span{\`o} and Gal{\'a}n, {Jorge E}",
year = "2008",
month = "2",
doi = "10.1016/j.mib.2007.12.002",
language = "English",
volume = "11",
pages = "15--20",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - A novel pathway for exotoxin delivery by an intracellular pathogen

AU - Spanò, Stefania

AU - Galán, Jorge E

PY - 2008/2

Y1 - 2008/2

N2 - Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.

AB - Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.

KW - animals

KW - bacterial toxins

KW - exotoxins

KW - humans

KW - models, biological

KW - Salmonella typhi

U2 - 10.1016/j.mib.2007.12.002

DO - 10.1016/j.mib.2007.12.002

M3 - Article

C2 - 18243772

VL - 11

SP - 15

EP - 20

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 1

ER -