A novel pathway for exotoxin delivery by an intracellular pathogen

Stefania Spanò, Jorge E Galán

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.
Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalCurrent Opinion in Microbiology
Volume11
Issue number1
Early online date20 Feb 2008
DOIs
Publication statusPublished - Feb 2008

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Keywords

  • animals
  • bacterial toxins
  • exotoxins
  • humans
  • models, biological
  • Salmonella typhi

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