A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization

Daniel J Macqueen, Ian A Johnston

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A novel myoD paralogue was characterised in Salmo salar (smyoD1c) and S. trutta (btmyoD1c). SmyoD1c had 78.2/90.6% protein sequence identity to smyoD1a/smyoD1b, respectively. Each paralogue was differentially expressed throughout somitogenesis. In adult fish, smyoD1a was the predominant gene expressed in fast muscle, whereas smyoD1c was 2-3 times upregulated in slow muscle compared to smyoD1a/1b. A maximum likelihood analysis indicated that myoD1c arose by duplication of myoD1b after the salmonid tetraploidization. Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature.
Original languageEnglish
Pages (from-to)4996-5002
Number of pages7
JournalFEBS Letters
Volume580
Issue number21
DOIs
Publication statusPublished - 2006

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