A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization

Daniel J Macqueen; Ian A Johnston

doi:10.1016/j.febslet.2006.08.016

A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization

Daniel J Macqueen, Ian A Johnston

Aberdeen Centre For Environmental Sustainability

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A novel myoD paralogue was characterised in Salmo salar (smyoD1c) and S. trutta (btmyoD1c). SmyoD1c had 78.2/90.6% protein sequence identity to smyoD1a/smyoD1b, respectively. Each paralogue was differentially expressed throughout somitogenesis. In adult fish, smyoD1a was the predominant gene expressed in fast muscle, whereas smyoD1c was 2-3 times upregulated in slow muscle compared to smyoD1a/1b. A maximum likelihood analysis indicated that myoD1c arose by duplication of myoD1b after the salmonid tetraploidization. Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature.

Original language	English
Pages (from-to)	4996-5002
Number of pages	7
Journal	FEBS Letters
Volume	580
Issue number	21
DOIs	https://doi.org/10.1016/j.febslet.2006.08.016
Publication status	Published - 2006

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title = "A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization",

abstract = "A novel myoD paralogue was characterised in Salmo salar (smyoD1c) and S. trutta (btmyoD1c). SmyoD1c had 78.2/90.6% protein sequence identity to smyoD1a/smyoD1b, respectively. Each paralogue was differentially expressed throughout somitogenesis. In adult fish, smyoD1a was the predominant gene expressed in fast muscle, whereas smyoD1c was 2-3 times upregulated in slow muscle compared to smyoD1a/1b. A maximum likelihood analysis indicated that myoD1c arose by duplication of myoD1b after the salmonid tetraploidization. Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature.",

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T1 - A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization

AU - Macqueen, Daniel J

AU - Johnston, Ian A

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AB - A novel myoD paralogue was characterised in Salmo salar (smyoD1c) and S. trutta (btmyoD1c). SmyoD1c had 78.2/90.6% protein sequence identity to smyoD1a/smyoD1b, respectively. Each paralogue was differentially expressed throughout somitogenesis. In adult fish, smyoD1a was the predominant gene expressed in fast muscle, whereas smyoD1c was 2-3 times upregulated in slow muscle compared to smyoD1a/1b. A maximum likelihood analysis indicated that myoD1c arose by duplication of myoD1b after the salmonid tetraploidization. Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature.

U2 - 10.1016/j.febslet.2006.08.016

DO - 10.1016/j.febslet.2006.08.016

M3 - Article

C2 - 16930594

SN - 0014-5793

VL - 580

SP - 4996

EP - 5002

JO - FEBS Letters

JF - FEBS Letters

IS - 21

ER -

A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization

Abstract

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