A panel study of air pollution in subjects with heart failure

negative results in treated patients

J L Barclay, B.G. Miller, S Dick, M Dennekamp, I Ford, G S Hillis, J G Ayres, A Seaton

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objectives: To investigate preclinical adverse effects of ambient particulate air pollution and nitrogen oxides in patients with heart failure.

Methods: A cohort of 132 non-smoking patients living in Aberdeen, Scotland, with stable chronic heart failure were enrolled in a repeated-measures panel study. Patients with atrial fibrillation or pacemakers were excluded. Participants were studied for 3 days every 2 months for up to 1 year with monitoring of pollutant exposure and concurrent measurements of pathophysiological responses. Measurements included daily area concentration of particulate matter with a median aerodynamic diameter of <10 micrometres (PM10), particle number concentration (PNC) and nitrogen oxides; daily estimated personal concentration of particulate matter with a median aerodynamic diameter of <2.5 micrometres (PM2.5) and PNC exposures; and 3-day cumulative personal nitrogen dioxide (NO2). Concurrent meteorological data were recorded. Blood was taken at the end of each 3-day block for assays of markers of endothelial activation, inflammation and coagulation. Cardiac rhythm was monitored by ambulatory Holter monitor during the final 24 h of each block.

Results: The average 24 h background ambient PM10 ranged from 7.4 to 68 µg.m-3 and PNC from 454 to 11¿283 particles.cm-3. No associations were demonstrated between the incidence of arrhythmias, heart rate variability or haematological/biochemical measures and any variations in pollutant exposures at any lags.

Conclusion: Assuming that low-level pollution affects the parameters measured, these findings may suggest a beneficial effect of modern cardioprotective therapy, which may modify responses to external risk factors. Widespread use of such drugs in susceptible populations may in future reduce the adverse effects of air pollution on the heart.
Original languageEnglish
Pages (from-to)325-334
Number of pages9
JournalOccupational and Environmental Medicine
Volume66
Issue number5
Early online date18 Nov 2008
DOIs
Publication statusPublished - May 2009

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Air Pollution
Nitrogen Oxides
Particulate Matter
Heart Failure
Nitrogen Dioxide
Scotland
Atrial Fibrillation
Cardiac Arrhythmias
Heart Rate
Inflammation
Incidence
Pharmaceutical Preparations
Population
Therapeutics

Cite this

A panel study of air pollution in subjects with heart failure : negative results in treated patients. / Barclay, J L; Miller, B.G.; Dick, S; Dennekamp, M; Ford, I; Hillis, G S; Ayres, J G; Seaton, A.

In: Occupational and Environmental Medicine, Vol. 66, No. 5, 05.2009, p. 325-334.

Research output: Contribution to journalArticle

Barclay, J L ; Miller, B.G. ; Dick, S ; Dennekamp, M ; Ford, I ; Hillis, G S ; Ayres, J G ; Seaton, A. / A panel study of air pollution in subjects with heart failure : negative results in treated patients. In: Occupational and Environmental Medicine. 2009 ; Vol. 66, No. 5. pp. 325-334.
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