A parallel group double-blind RCT of vitamin D3 assessing physical function

is the biochemical response to treatment affected by overweight and obesity?

A D Wood, K R Secombes, F Thies, L S Aucott, A J Black, D M Reid, A Mavroeidi, W G Simpson, W D Fraser, H M Macdonald

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D-3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.

This study aimed to test the supplementation effects of vitamin D-3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment.

In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude-57A degrees N) aged 60-70 years (body mass index (BMI), 18-45 kg/m(2)) were assigned (computer randomisation) to daily vitamin D-3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.

Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D-3 and placebo groups, respectively (P = .10, ANOVA)) or falls (P = .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25-29.99, a parts per thousand yen30 kg/m(2)) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (P = .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (r = -.268), BMI (r = -.198), total (r = -.278) and trunk fat mass (r = -.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (P = .01/.004 respectively, linear regression).

We found no evidence of an improvement in physical function following vitamin D-3 supplementation for 1 year.

Original languageEnglish
Pages (from-to)305-315
Number of pages11
JournalOsteoporosis International
Volume25
Issue number1
Early online date28 Aug 2013
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Accidental Falls
  • Aged
  • Anthropometry
  • Body Composition
  • Body Mass Index
  • Calcium
  • Cholecalciferol
  • Diet
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Hand Strength
  • Humans
  • Middle Aged
  • Motor Activity
  • Obesity
  • Overweight
  • Phosphates
  • Sunlight
  • Vitamin D
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

Cite this

A parallel group double-blind RCT of vitamin D3 assessing physical function : is the biochemical response to treatment affected by overweight and obesity? / Wood, A D; Secombes, K R; Thies, F; Aucott, L S; Black, A J; Reid, D M; Mavroeidi, A; Simpson, W G; Fraser, W D; Macdonald, H M.

In: Osteoporosis International, Vol. 25, No. 1, 01.2014, p. 305-315.

Research output: Contribution to journalArticle

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title = "A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?",
abstract = "Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D-3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.This study aimed to test the supplementation effects of vitamin D-3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment.In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude-57A degrees N) aged 60-70 years (body mass index (BMI), 18-45 kg/m(2)) were assigned (computer randomisation) to daily vitamin D-3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D-3 and placebo groups, respectively (P = .10, ANOVA)) or falls (P = .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25-29.99, a parts per thousand yen30 kg/m(2)) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (P = .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (r = -.268), BMI (r = -.198), total (r = -.278) and trunk fat mass (r = -.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (P = .01/.004 respectively, linear regression).We found no evidence of an improvement in physical function following vitamin D-3 supplementation for 1 year.",
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N2 - Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D-3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.This study aimed to test the supplementation effects of vitamin D-3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment.In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude-57A degrees N) aged 60-70 years (body mass index (BMI), 18-45 kg/m(2)) were assigned (computer randomisation) to daily vitamin D-3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D-3 and placebo groups, respectively (P = .10, ANOVA)) or falls (P = .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25-29.99, a parts per thousand yen30 kg/m(2)) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (P = .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (r = -.268), BMI (r = -.198), total (r = -.278) and trunk fat mass (r = -.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (P = .01/.004 respectively, linear regression).We found no evidence of an improvement in physical function following vitamin D-3 supplementation for 1 year.

AB - Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D-3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.This study aimed to test the supplementation effects of vitamin D-3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment.In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude-57A degrees N) aged 60-70 years (body mass index (BMI), 18-45 kg/m(2)) were assigned (computer randomisation) to daily vitamin D-3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D-3 and placebo groups, respectively (P = .10, ANOVA)) or falls (P = .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25-29.99, a parts per thousand yen30 kg/m(2)) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (P = .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (r = -.268), BMI (r = -.198), total (r = -.278) and trunk fat mass (r = -.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (P = .01/.004 respectively, linear regression).We found no evidence of an improvement in physical function following vitamin D-3 supplementation for 1 year.

KW - Accidental Falls

KW - Aged

KW - Anthropometry

KW - Body Composition

KW - Body Mass Index

KW - Calcium

KW - Cholecalciferol

KW - Diet

KW - Dietary Supplements

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Female

KW - Hand Strength

KW - Humans

KW - Middle Aged

KW - Motor Activity

KW - Obesity

KW - Overweight

KW - Phosphates

KW - Sunlight

KW - Vitamin D

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/s00198-013-2473-8

DO - 10.1007/s00198-013-2473-8

M3 - Article

VL - 25

SP - 305

EP - 315

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 1

ER -