A pharmacokinetic PET study of NK(1) receptor occupancy

Stefano Zamuner; Eugenii A Rabiner; Sofia A Fernandes; Massimo Bani; Roger N Gunn; Roberto Gomeni; Emilangelo Ratti; Vincent J Cunningham

doi:10.1007/s00259-011-1954-2

A pharmacokinetic PET study of NK(1) receptor occupancy

Stefano Zamuner, Eugenii A Rabiner, Sofia A Fernandes, Massimo Bani, Roger N Gunn, Roberto Gomeni, Emilangelo Ratti, Vincent J Cunningham

Applied Medicine

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

There is growing recognition of the importance of integrating drug occupancy data acquired by positron emission tomography (PET) with the plasma pharmacokinetics of the drug, in order to establish proper dose selection in subsequent clinical trials. Here we present a study in human subjects of the occupancy of NK(1) receptors achieved following different doses of casopitant, a selective NK(1) antagonist.

Original language	English
Pages (from-to)	226-235
Number of pages	10
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	39
Issue number	2
Early online date	13 Oct 2011
DOIs	https://doi.org/10.1007/s00259-011-1954-2
Publication status	Published - Feb 2012

Keywords

positron emission tomography
pharmacokinetics
NK1 receptors
kinetic modelling
population approach

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10.1007/s00259-011-1954-2

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AU - Fernandes, Sofia A

AU - Bani, Massimo

AU - Gunn, Roger N

AU - Gomeni, Roberto

AU - Ratti, Emilangelo

AU - Cunningham, Vincent J

PY - 2012/2

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KW - positron emission tomography

KW - pharmacokinetics

KW - NK1 receptors

KW - kinetic modelling

KW - population approach

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DO - 10.1007/s00259-011-1954-2

M3 - Article

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A pharmacokinetic PET study of NK(1) receptor occupancy

Abstract

Keywords

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