A pharmacokinetic PET study of NK(1) receptor occupancy

Stefano Zamuner, Eugenii A Rabiner, Sofia A Fernandes, Massimo Bani, Roger N Gunn, Roberto Gomeni, Emilangelo Ratti, Vincent J Cunningham

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Abstract

There is growing recognition of the importance of integrating drug occupancy data acquired by positron emission tomography (PET) with the plasma pharmacokinetics of the drug, in order to establish proper dose selection in subsequent clinical trials. Here we present a study in human subjects of the occupancy of NK(1) receptors achieved following different doses of casopitant, a selective NK(1) antagonist.
Original languageEnglish
Pages (from-to)226-235
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume39
Issue number2
Early online date13 Oct 2011
DOIs
Publication statusPublished - Feb 2012

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Keywords

  • positron emission tomography
  • pharmacokinetics
  • NK1 receptors
  • kinetic modelling
  • population approach

Cite this

Zamuner, S., Rabiner, E. A., Fernandes, S. A., Bani, M., Gunn, R. N., Gomeni, R., ... Cunningham, V. J. (2012). A pharmacokinetic PET study of NK(1) receptor occupancy. European Journal of Nuclear Medicine and Molecular Imaging, 39(2), 226-235. https://doi.org/10.1007/s00259-011-1954-2