A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation

Haitham Hamoda, Premila Wencesiaus Ashok, G. M. Flett, J. Dow, Alexander Allan Templeton

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Of the total women included in the study, 96 women chose to receive misoprostol 600 mug sublingually while 53 women received misoprostol 800 mug vaginally 36-48 h after receiving mifepristone 200 mg. Complete abortion occurred in 93 women (98.9%) in the sublingual and 51 women (96.2%) in the vaginal group (p=0.27). The mean induction-to-abortion interval was 3.2 h (SD=1.4) in the sublingual and 4.1 h (SD=1.5) in the vaginal group (p=0.02). The mean gestation at abortion in weeks was 7.1 (SD=1.0) in the sublingual and 7.7 (SD=1.3) in the vaginal group (p=0.003). Women in the sublingual group experienced more vomiting (p=0.03), diarrhea (p=0.02) and unpleasant taste in their mouth (p=0.0001) while those in the vaginal group experienced more headache (p=0.002). Of women in the sublingual group, 77% were satisfied with the route of misoprostol administration compared to 68% in the vaginal group (p=0.25). These findings now need to be assessed in the context of a randomized controlled trial. (C) 2003 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)335-338
Number of pages3
JournalContraception
Volume68
Issue number5
DOIs
Publication statusPublished - 2003

Keywords

  • sublingual
  • misoprostol
  • medical abortion
  • mifepristone
  • SURGICAL VACUUM ASPIRATION
  • ABORTION
  • EFFICACY
  • ACCEPTABILITY

Cite this

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title = "A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation",
abstract = "Of the total women included in the study, 96 women chose to receive misoprostol 600 mug sublingually while 53 women received misoprostol 800 mug vaginally 36-48 h after receiving mifepristone 200 mg. Complete abortion occurred in 93 women (98.9{\%}) in the sublingual and 51 women (96.2{\%}) in the vaginal group (p=0.27). The mean induction-to-abortion interval was 3.2 h (SD=1.4) in the sublingual and 4.1 h (SD=1.5) in the vaginal group (p=0.02). The mean gestation at abortion in weeks was 7.1 (SD=1.0) in the sublingual and 7.7 (SD=1.3) in the vaginal group (p=0.003). Women in the sublingual group experienced more vomiting (p=0.03), diarrhea (p=0.02) and unpleasant taste in their mouth (p=0.0001) while those in the vaginal group experienced more headache (p=0.002). Of women in the sublingual group, 77{\%} were satisfied with the route of misoprostol administration compared to 68{\%} in the vaginal group (p=0.25). These findings now need to be assessed in the context of a randomized controlled trial. (C) 2003 Elsevier Inc. All rights reserved.",
keywords = "sublingual, misoprostol, medical abortion, mifepristone, SURGICAL VACUUM ASPIRATION, ABORTION, EFFICACY, ACCEPTABILITY",
author = "Haitham Hamoda and Ashok, {Premila Wencesiaus} and Flett, {G. M.} and J. Dow and Templeton, {Alexander Allan}",
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T1 - A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation

AU - Hamoda, Haitham

AU - Ashok, Premila Wencesiaus

AU - Flett, G. M.

AU - Dow, J.

AU - Templeton, Alexander Allan

PY - 2003

Y1 - 2003

N2 - Of the total women included in the study, 96 women chose to receive misoprostol 600 mug sublingually while 53 women received misoprostol 800 mug vaginally 36-48 h after receiving mifepristone 200 mg. Complete abortion occurred in 93 women (98.9%) in the sublingual and 51 women (96.2%) in the vaginal group (p=0.27). The mean induction-to-abortion interval was 3.2 h (SD=1.4) in the sublingual and 4.1 h (SD=1.5) in the vaginal group (p=0.02). The mean gestation at abortion in weeks was 7.1 (SD=1.0) in the sublingual and 7.7 (SD=1.3) in the vaginal group (p=0.003). Women in the sublingual group experienced more vomiting (p=0.03), diarrhea (p=0.02) and unpleasant taste in their mouth (p=0.0001) while those in the vaginal group experienced more headache (p=0.002). Of women in the sublingual group, 77% were satisfied with the route of misoprostol administration compared to 68% in the vaginal group (p=0.25). These findings now need to be assessed in the context of a randomized controlled trial. (C) 2003 Elsevier Inc. All rights reserved.

AB - Of the total women included in the study, 96 women chose to receive misoprostol 600 mug sublingually while 53 women received misoprostol 800 mug vaginally 36-48 h after receiving mifepristone 200 mg. Complete abortion occurred in 93 women (98.9%) in the sublingual and 51 women (96.2%) in the vaginal group (p=0.27). The mean induction-to-abortion interval was 3.2 h (SD=1.4) in the sublingual and 4.1 h (SD=1.5) in the vaginal group (p=0.02). The mean gestation at abortion in weeks was 7.1 (SD=1.0) in the sublingual and 7.7 (SD=1.3) in the vaginal group (p=0.003). Women in the sublingual group experienced more vomiting (p=0.03), diarrhea (p=0.02) and unpleasant taste in their mouth (p=0.0001) while those in the vaginal group experienced more headache (p=0.002). Of women in the sublingual group, 77% were satisfied with the route of misoprostol administration compared to 68% in the vaginal group (p=0.25). These findings now need to be assessed in the context of a randomized controlled trial. (C) 2003 Elsevier Inc. All rights reserved.

KW - sublingual

KW - misoprostol

KW - medical abortion

KW - mifepristone

KW - SURGICAL VACUUM ASPIRATION

KW - ABORTION

KW - EFFICACY

KW - ACCEPTABILITY

U2 - 10.1016/j.contraception.2003.07.004

DO - 10.1016/j.contraception.2003.07.004

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JO - Contraception

JF - Contraception

SN - 0010-7824

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ER -