A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation

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Abstract

Of the total women included in the study, 96 women chose to receive misoprostol 600 mug sublingually while 53 women received misoprostol 800 mug vaginally 36-48 h after receiving mifepristone 200 mg. Complete abortion occurred in 93 women (98.9%) in the sublingual and 51 women (96.2%) in the vaginal group (p=0.27). The mean induction-to-abortion interval was 3.2 h (SD=1.4) in the sublingual and 4.1 h (SD=1.5) in the vaginal group (p=0.02). The mean gestation at abortion in weeks was 7.1 (SD=1.0) in the sublingual and 7.7 (SD=1.3) in the vaginal group (p=0.003). Women in the sublingual group experienced more vomiting (p=0.03), diarrhea (p=0.02) and unpleasant taste in their mouth (p=0.0001) while those in the vaginal group experienced more headache (p=0.002). Of women in the sublingual group, 77% were satisfied with the route of misoprostol administration compared to 68% in the vaginal group (p=0.25). These findings now need to be assessed in the context of a randomized controlled trial. (C) 2003 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)335-338
Number of pages3
JournalContraception
Volume68
Issue number5
DOIs
Publication statusPublished - 2003

Keywords

  • sublingual
  • misoprostol
  • medical abortion
  • mifepristone
  • SURGICAL VACUUM ASPIRATION
  • ABORTION
  • EFFICACY
  • ACCEPTABILITY

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