A population based case control study of aetiological factors associated with vulval lichen sclerosus

Claire Higgins (Corresponding Author), Maggie Cruickshank

Research output: Contribution to journalArticle

24 Citations (Scopus)
7 Downloads (Pure)

Abstract

We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n=¿92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n=¿66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR=¿7.0, p=¿0.012) and previous pelvic surgery (OR=¿4.75, p=¿0.007). The use of barrier and progesterone only methods of contraception (OR=¿0.19, p=¿0.045), hormone replacement therapy (OR=¿0.209, p=¿0.025) or hayfever (OR=¿0.18, p=¿0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalJournal of Obstetrics and Gynaecology
Volume32
Issue number3
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Lichen Sclerosus et Atrophicus
Case-Control Studies
Population
Seasonal Allergic Rhinitis
Hormone Replacement Therapy
Autoimmunity
Gynecology
Contraception
Skin Diseases
Progesterone
Diabetes Mellitus

Keywords

  • Dermatology
  • aetiology
  • autoimmune disease
  • Vulvar Diseases

Cite this

A population based case control study of aetiological factors associated with vulval lichen sclerosus. / Higgins, Claire (Corresponding Author); Cruickshank, Maggie.

In: Journal of Obstetrics and Gynaecology, Vol. 32, No. 3, 04.2012, p. 271-275.

Research output: Contribution to journalArticle

@article{3d0ca7c3580243d39a4e64aca5b35524,
title = "A population based case control study of aetiological factors associated with vulval lichen sclerosus",
abstract = "We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n=¿92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n=¿66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR=¿7.0, p=¿0.012) and previous pelvic surgery (OR=¿4.75, p=¿0.007). The use of barrier and progesterone only methods of contraception (OR=¿0.19, p=¿0.045), hormone replacement therapy (OR=¿0.209, p=¿0.025) or hayfever (OR=¿0.18, p=¿0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.",
keywords = "Dermatology, aetiology, autoimmune disease, Vulvar Diseases",
author = "Claire Higgins and Maggie Cruickshank",
year = "2012",
month = "4",
doi = "10.3109/01443615.2011.649320",
language = "English",
volume = "32",
pages = "271--275",
journal = "Journal of Obstetrics and Gynaecology",
issn = "0144-3615",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - A population based case control study of aetiological factors associated with vulval lichen sclerosus

AU - Higgins, Claire

AU - Cruickshank, Maggie

PY - 2012/4

Y1 - 2012/4

N2 - We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n=¿92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n=¿66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR=¿7.0, p=¿0.012) and previous pelvic surgery (OR=¿4.75, p=¿0.007). The use of barrier and progesterone only methods of contraception (OR=¿0.19, p=¿0.045), hormone replacement therapy (OR=¿0.209, p=¿0.025) or hayfever (OR=¿0.18, p=¿0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.

AB - We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n=¿92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n=¿66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR=¿7.0, p=¿0.012) and previous pelvic surgery (OR=¿4.75, p=¿0.007). The use of barrier and progesterone only methods of contraception (OR=¿0.19, p=¿0.045), hormone replacement therapy (OR=¿0.209, p=¿0.025) or hayfever (OR=¿0.18, p=¿0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.

KW - Dermatology

KW - aetiology

KW - autoimmune disease

KW - Vulvar Diseases

U2 - 10.3109/01443615.2011.649320

DO - 10.3109/01443615.2011.649320

M3 - Article

VL - 32

SP - 271

EP - 275

JO - Journal of Obstetrics and Gynaecology

JF - Journal of Obstetrics and Gynaecology

SN - 0144-3615

IS - 3

ER -