A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

Clara Calvert; Jade Carruthers; Cheryl Denny; Jack Donaghy; Sam Hillman; Lisa E M Hopcroft; Leanne Hopkins; Anna Goulding; Laura Lindsay; Terry McLaughlin; Emily Moore; Jiafeng Pan; Bob Taylor; Fatima Almaghrabi; Bonnie Auyeung; Krishnan Bhaskaran; Cheryl L Gibbons; Srinivasa Vittal Katikireddi; Colin McCowan; Josie Murray; Maureen O'Leary; Lewis D Ritchie; Syed Ahmar Shah; Colin R Simpson; Chris Robertson; Aziz Sheikh; Sarah J Stock; Rachael Wood

doi:10.1038/s41467-022-33937-y

A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

Clara Calvert, Jade Carruthers, Cheryl Denny, Jack Donaghy, Sam Hillman, Lisa E M Hopcroft, Leanne Hopkins, Anna Goulding, Laura Lindsay, Terry McLaughlin, Emily Moore, Jiafeng Pan, Bob Taylor, Fatima Almaghrabi, Bonnie Auyeung, Krishnan Bhaskaran, Cheryl L Gibbons, Srinivasa Vittal Katikireddi, Colin McCowan, Josie MurrayMaureen O'Leary, Lewis D Ritchie, Syed Ahmar Shah, Colin R Simpson, Chris Robertson, Aziz Sheikh, Sarah J Stock, Rachael Wood

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.

Original language	English
Article number	6124
Number of pages	10
Journal	Nature Communications
Volume	13
Issue number	1
Early online date	17 Oct 2022
DOIs	https://doi.org/10.1038/s41467-022-33937-y
Publication status	Published - 17 Oct 2022

Keywords

epidemiology
SARS-CoV-2
viral infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41467-022-33937-yLicence: CC BY

Calvert_etal_NC_Population_Based_Matched_VOR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 876 KBLicence: CC BY

Cite this

Calvert, C., Carruthers, J., Denny, C., Donaghy, J., Hillman, S., Hopcroft, L. E. M., Hopkins, L., Goulding, A., Lindsay, L., McLaughlin, T., Moore, E., Pan, J., Taylor, B., Almaghrabi, F., Auyeung, B., Bhaskaran, K., Gibbons, C. L., Katikireddi, S. V., McCowan, C., ... Wood, R. (2022). A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection. Nature Communications, 13(1), [6124]. https://doi.org/10.1038/s41467-022-33937-y

Calvert, C, Carruthers, J, Denny, C, Donaghy, J, Hillman, S, Hopcroft, LEM, Hopkins, L, Goulding, A, Lindsay, L, McLaughlin, T, Moore, E, Pan, J, Taylor, B, Almaghrabi, F, Auyeung, B, Bhaskaran, K, Gibbons, CL, Katikireddi, SV, McCowan, C, Murray, J, O'Leary, M, Ritchie, LD, Shah, SA, Simpson, CR, Robertson, C, Sheikh, A, Stock, SJ & Wood, R 2022, 'A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection', Nature Communications, vol. 13, no. 1, 6124. https://doi.org/10.1038/s41467-022-33937-y

@article{a26c17df5aa64245b65842579892f39e,

title = "A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection",

abstract = "Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.",

keywords = "epidemiology, SARS-CoV-2, viral infection",

author = "Clara Calvert and Jade Carruthers and Cheryl Denny and Jack Donaghy and Sam Hillman and Hopcroft, {Lisa E M} and Leanne Hopkins and Anna Goulding and Laura Lindsay and Terry McLaughlin and Emily Moore and Jiafeng Pan and Bob Taylor and Fatima Almaghrabi and Bonnie Auyeung and Krishnan Bhaskaran and Gibbons, {Cheryl L} and Katikireddi, {Srinivasa Vittal} and Colin McCowan and Josie Murray and Maureen O'Leary and Ritchie, {Lewis D} and Shah, {Syed Ahmar} and Simpson, {Colin R} and Chris Robertson and Aziz Sheikh and Stock, {Sarah J} and Rachael Wood",

note = "Our thanks to the EAVE II Patient Advisory Group and Sands charity for their support. COPS is a sub-study of EAVE II, which is funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE—The Health Data Research Hub for Respiratory Health [MC_PC_19004], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through Public Health Scotland and Scottish Government DG Health and Social Care and the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation. COPS has received additional funding from Tommy{\textquoteright}s charity. S.J.S. is funded by a Wellcome Trust Clinical Career Development Fellowship (209560/Z/17/Z). S.V.K. acknowledges funding from an NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). K.B. is funded by a Wellcome Senior Research Fellowship (220283/Z/20/Z). ",

year = "2022",

month = oct,

day = "17",

doi = "10.1038/s41467-022-33937-y",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

AU - Calvert, Clara

AU - Carruthers, Jade

AU - Denny, Cheryl

AU - Donaghy, Jack

AU - Hillman, Sam

AU - Hopcroft, Lisa E M

AU - Hopkins, Leanne

AU - Goulding, Anna

AU - Lindsay, Laura

AU - McLaughlin, Terry

AU - Moore, Emily

AU - Pan, Jiafeng

AU - Taylor, Bob

AU - Almaghrabi, Fatima

AU - Auyeung, Bonnie

AU - Bhaskaran, Krishnan

AU - Gibbons, Cheryl L

AU - Katikireddi, Srinivasa Vittal

AU - McCowan, Colin

AU - Murray, Josie

AU - O'Leary, Maureen

AU - Ritchie, Lewis D

AU - Shah, Syed Ahmar

AU - Simpson, Colin R

AU - Robertson, Chris

AU - Sheikh, Aziz

AU - Stock, Sarah J

AU - Wood, Rachael

N1 - Our thanks to the EAVE II Patient Advisory Group and Sands charity for their support. COPS is a sub-study of EAVE II, which is funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE—The Health Data Research Hub for Respiratory Health [MC_PC_19004], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through Public Health Scotland and Scottish Government DG Health and Social Care and the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation. COPS has received additional funding from Tommy’s charity. S.J.S. is funded by a Wellcome Trust Clinical Career Development Fellowship (209560/Z/17/Z). S.V.K. acknowledges funding from an NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). K.B. is funded by a Wellcome Senior Research Fellowship (220283/Z/20/Z).

PY - 2022/10/17

Y1 - 2022/10/17

N2 - Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.

AB - Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.

KW - epidemiology

KW - SARS-CoV-2

KW - viral infection

UR - http://www.scopus.com/inward/record.url?scp=85140015609&partnerID=8YFLogxK

U2 - 10.1038/s41467-022-33937-y

DO - 10.1038/s41467-022-33937-y

M3 - Article

C2 - 36253471

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 6124

ER -

A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this