A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout

Christyn Bailey* (Corresponding Author), Jason W Holland, Christopher J Secombes, Carolina Tafalla

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Downloads (Pure)

Abstract

Proliferative kidney disease (PKD), caused by the myxozoan Tetracapsuloides bryosalmonae, is one of the most serious parasitic diseases of salmonids in which outbreaks cause severe economic constraints for the aquaculture industry and declines of wild species throughout Europe and North America. Given that rainbow trout (Oncorhynchus mykiss) is one of the most widely farmed freshwater fish and an important model species for fish immunology, most of the knowledge on how the fish immune response is affected during PKD is from this organism. Once rainbow trout are infected, PKD pathogenesis results in a chronic kidney immunopathology mediated by decreasing myeloid cells and increasing lymphocytes. Transcriptional studies have revealed the regulation of essential genes related to T-helper (Th)-like functions and a dysregulated B-cell antibody type response. Recent reports have discovered unique details of teleost B-cell differentiation and functionality and characterized the differential immunoglobulin (Ig)-mediated response. These studies have solidified the rainbow trout T. bryosalmonae system as a sophisticated disease model capable of feeding key advances into mainstream immunology and have contributed essential information to design novel parasite disease prevention strategies. In our following perspective, we summarize these efforts to evaluate the immune mechanisms of rainbow trout during PKD pathogenesis.

Original languageEnglish
Article numbere12730
Number of pages13
JournalParasite Immunology
Volume42
Issue number8
Early online date31 May 2020
DOIs
Publication statusE-pub ahead of print - 31 May 2020

Keywords

  • immunoglobulin
  • immunopathology
  • Lymphocytes
  • Myxozoa
  • Salmonids
  • Tetracapsuloides bryosalmonae
  • CHANNEL CATFISH
  • lymphocytes
  • EXPRESSION ANALYSIS
  • DIFFERENTIAL EXPRESSION
  • salmonids
  • immunoglobulins
  • ONCORHYNCHUS-MYKISS WALBAUM
  • BROWN TROUT
  • SALMO-TRUTTA
  • TETRACAPSULOIDES-BRYOSALMONAE
  • GOLDFISH CARASSIUS-AURATUS
  • TOLL-LIKE RECEPTORS
  • myxozoa
  • T-CELLS

Fingerprint Dive into the research topics of 'A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout'. Together they form a unique fingerprint.

  • Cite this