A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

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Abstract

OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.

METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.

RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.

CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

Original languageEnglish
Pages (from-to)500-510
Number of pages11
JournalRheumatology
Volume54
Issue number3
Early online date10 Sep 2014
DOIs
Publication statusPublished - Mar 2015

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Periodontitis
Ankylosing Spondylitis
Meta-Analysis
Publication Bias
Case-Control Studies
Odds Ratio

Keywords

  • ankylosing spondylitis
  • periodontitis
  • epidemiology
  • prevalence
  • dental

Cite this

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title = "A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis",
abstract = "OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38{\%} to 88{\%} in AS patients and from 26{\%} to 71{\%} in controls. As there was low-level heterogeneity (I(2) = 13{\%}), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95{\%} CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.",
keywords = "ankylosing spondylitis , periodontitis, epidemiology, prevalence, dental",
author = "Tiara Ratz and Dean, {Linda E} and Fabiola Atzeni and Christopher Reeks and Macfarlane, {Gary J} and Tatiana MacFarlane",
note = "{\circledC} The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Acknowledgements We are grateful to Melanie Bickerton, from the Medical Library University of Aberdeen, and Dr Simon Stebbings Professor W. Murray Thompson and Associate Professor Mary P. Cullinan for providing additional information about their studies. T.R. worked on the project while taking part in an Erasmus student placement under the European Lifelong Learning Programme. L.D. received funding from the Medical Research Council to undertake her PhD. Disclosure statement: The authors have declared no conflicts of interest.",
year = "2015",
month = "3",
doi = "10.1093/rheumatology/keu356",
language = "English",
volume = "54",
pages = "500--510",
journal = "Rheumatology",
issn = "1462-0324",
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T2 - a systematic review and meta-analysis

AU - Ratz, Tiara

AU - Dean, Linda E

AU - Atzeni, Fabiola

AU - Reeks, Christopher

AU - Macfarlane, Gary J

AU - MacFarlane, Tatiana

N1 - © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Acknowledgements We are grateful to Melanie Bickerton, from the Medical Library University of Aberdeen, and Dr Simon Stebbings Professor W. Murray Thompson and Associate Professor Mary P. Cullinan for providing additional information about their studies. T.R. worked on the project while taking part in an Erasmus student placement under the European Lifelong Learning Programme. L.D. received funding from the Medical Research Council to undertake her PhD. Disclosure statement: The authors have declared no conflicts of interest.

PY - 2015/3

Y1 - 2015/3

N2 - OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

AB - OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

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KW - periodontitis

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KW - prevalence

KW - dental

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