A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines

Andrea Bilger, L Michelle Bennett, Reynaldo A Carabeo, Teresa A Chiaverotti, Cecily Dvorak, Kristin M Liss, Susan A Schadewald, Henry C Pitot, Norman R Drinkwater

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34 Citations (Scopus)

Abstract

The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P <10(-11), in males; 3- to 4-fold, P <10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.
Original languageEnglish
Pages (from-to)859-66
Number of pages8
JournalGenetics
Volume167
Issue number2
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Liver Neoplasms
  • Risk
  • Animals
  • Rodent Diseases
  • Mice
  • Species Specificity
  • Chromosome Mapping

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    Bilger, A., Bennett, L. M., Carabeo, R. A., Chiaverotti, T. A., Dvorak, C., Liss, K. M., Schadewald, S. A., Pitot, H. C., & Drinkwater, N. R. (2004). A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics, 167(2), 859-66. https://doi.org/10.1534/genetics.103.024521