Abstract
The objective of this study was to compare the frequency of two common p21(WAF1/Cip1) gene polymorphisms in ovarian cancer patients with that in age-matched controls, from a population originating from Eastern Scotland. Both polymorphisms were found significantly less frequently in both the constitutive and tumour tissue DNA of ovarian cancer patients (3/65; 4.6%), than in that from geographically and age-matched controls (25/186; 13.4%) (p=0.0495, chi(2)). Furthermore, we found no p21(WAF1/Cip1) gene mutations in any of the tumours, reflected by a relatively low degree of loss of heterozygosity (LOH) at the chromosomal region where the gene maps, providing further evidence that the p21(WAF1/Cip1) gene is not mutated in ovarian cancer. The data suggest however, that there may potentially be a protective function for the two p21(WAF1/Cip1) gene polymorphisms in the population under study.
| Original language | English |
|---|---|
| Pages (from-to) | 117-119 |
| Number of pages | 3 |
| Journal | International Journal of Oncology |
| Volume | 15 |
| Publication status | Published - 1999 |
Keywords
- p21(WAF1/Cip1)
- ovarian cancer
- polymorphism
- WAF1/CIP1 GENE
- ALLELIC DELETION
- CODING REGION
- P53 MUTATION
- CARCINOMA
- TUMOR
- OVEREXPRESSION
- EXPRESSION
- INHIBITOR
- CODON-31
