A protective role for common p21(WAF1/Cip1) polymorphisms in human ovarian cancer

B J Milner, I Brown, H Gabra, H C Kitchener, D E Parkin, N E Haites

Research output: Contribution to journalArticle

Abstract

The objective of this study was to compare the frequency of two common p21(WAF1/Cip1) gene polymorphisms in ovarian cancer patients with that in age-matched controls, from a population originating from Eastern Scotland. Both polymorphisms were found significantly less frequently in both the constitutive and tumour tissue DNA of ovarian cancer patients (3/65; 4.6%), than in that from geographically and age-matched controls (25/186; 13.4%) (p=0.0495, chi(2)). Furthermore, we found no p21(WAF1/Cip1) gene mutations in any of the tumours, reflected by a relatively low degree of loss of heterozygosity (LOH) at the chromosomal region where the gene maps, providing further evidence that the p21(WAF1/Cip1) gene is not mutated in ovarian cancer. The data suggest however, that there may potentially be a protective function for the two p21(WAF1/Cip1) gene polymorphisms in the population under study.

Original languageEnglish
Pages (from-to)117-119
Number of pages3
JournalInternational Journal of Oncology
Volume15
Publication statusPublished - 1999

Keywords

  • p21(WAF1/Cip1)
  • ovarian cancer
  • polymorphism
  • WAF1/CIP1 GENE
  • ALLELIC DELETION
  • CODING REGION
  • P53 MUTATION
  • CARCINOMA
  • TUMOR
  • OVEREXPRESSION
  • EXPRESSION
  • INHIBITOR
  • CODON-31

Cite this

Milner, B. J., Brown, I., Gabra, H., Kitchener, H. C., Parkin, D. E., & Haites, N. E. (1999). A protective role for common p21(WAF1/Cip1) polymorphisms in human ovarian cancer. International Journal of Oncology, 15, 117-119.