A question about the reliability of a recent trial of progesterone for preterm birth prevention, published in Acta

Emmanouil Katsanevakis*, Ben W. Mol, Jim Thornton

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)

Abstract

We noticed that in 2017 Acta published a registered placebo‐controlled randomized clinical trial (NCT02571296) with a statistically significant positive result.1 This is unusual (as stated by Prior et al).2 Among women with a past history of spontaneous preterm delivery at <37 weeks, 100 mg oral micronized progesterone, 6‐hourly, starting at 14‐18 weeks, significantly reduced the primary outcome of birth before 37 weeks compared with placebo.
Original languageEnglish
Pages (from-to)426
Number of pages1
JournalActa Obstetricia et Gynecologica Scandinavica
Volume99
Issue number3
Early online date8 Dec 2019
DOIs
Publication statusPublished - Mar 2020

Keywords

  • DOUBLE-BLIND
  • MULTICENTER

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