A randomised controlled trial evaluating the use of polyglactin (Vicryl) mesh, polydioxanone (PDS) or polyglactin (Vicryl) sutures for pelvic organ prolapse surgery

outcomes at 2 years

P Madhuvrata, C Glazener, C Boachie, S Allahdin, C Bain

Research output: Contribution to journalArticle

16 Citations (Scopus)
4 Downloads (Pure)

Abstract

Summary The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 × 2 factorial design of Vicryl mesh (n¿=¿32) or not (n¿=¿34) and PDS (n¿=¿33) or Vicryl suture (n¿=¿33). The response rate at 2 years was 82%. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95% CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95% CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.
Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalJournal of Obstetrics and Gynaecology
Volume31
Issue number5
DOIs
Publication statusPublished - 2011

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Polydioxanone
Pelvic Organ Prolapse
Polyglactin 910
Sutures
Randomized Controlled Trials
Prolapse
Quality of Life
Urinary Incontinence
Inlays

Keywords

  • mesh
  • pelvic organ prolapse
  • polydioxanone
  • polyglactin
  • sutures

Cite this

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title = "A randomised controlled trial evaluating the use of polyglactin (Vicryl) mesh, polydioxanone (PDS) or polyglactin (Vicryl) sutures for pelvic organ prolapse surgery: outcomes at 2 years",
abstract = "Summary The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 × 2 factorial design of Vicryl mesh (n¿=¿32) or not (n¿=¿34) and PDS (n¿=¿33) or Vicryl suture (n¿=¿33). The response rate at 2 years was 82{\%}. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95{\%} CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95{\%} CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.",
keywords = "mesh, pelvic organ prolapse, polydioxanone, polyglactin, sutures",
author = "P Madhuvrata and C Glazener and C Boachie and S Allahdin and C Bain",
year = "2011",
doi = "10.3109/01443615.2011.576282",
language = "English",
volume = "31",
pages = "429--435",
journal = "Journal of Obstetrics and Gynaecology",
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TY - JOUR

T1 - A randomised controlled trial evaluating the use of polyglactin (Vicryl) mesh, polydioxanone (PDS) or polyglactin (Vicryl) sutures for pelvic organ prolapse surgery

T2 - outcomes at 2 years

AU - Madhuvrata, P

AU - Glazener, C

AU - Boachie, C

AU - Allahdin, S

AU - Bain, C

PY - 2011

Y1 - 2011

N2 - Summary The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 × 2 factorial design of Vicryl mesh (n¿=¿32) or not (n¿=¿34) and PDS (n¿=¿33) or Vicryl suture (n¿=¿33). The response rate at 2 years was 82%. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95% CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95% CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.

AB - Summary The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 × 2 factorial design of Vicryl mesh (n¿=¿32) or not (n¿=¿34) and PDS (n¿=¿33) or Vicryl suture (n¿=¿33). The response rate at 2 years was 82%. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95% CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95% CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.

KW - mesh

KW - pelvic organ prolapse

KW - polydioxanone

KW - polyglactin

KW - sutures

U2 - 10.3109/01443615.2011.576282

DO - 10.3109/01443615.2011.576282

M3 - Article

VL - 31

SP - 429

EP - 435

JO - Journal of Obstetrics and Gynaecology

JF - Journal of Obstetrics and Gynaecology

SN - 0144-3615

IS - 5

ER -