A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes

S. C. Mcgeoch*, A. M. Johnstone, G. E. Lobley, J. Adamson, K. Hickson, G. Holtrop, C. Fyfe, L. F. Clark, D. W. M. Pearson, P. Abraham, I. L. Megson, S. M. Macrury

*Corresponding author for this work

Research output: Contribution to journalArticle

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Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat‐enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice.
Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8‐week periods following either the oat‐enriched diet or re‐enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3‐h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high‐sensitivity C‐reactive protein, interleukin 6, interleukin 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.
Results There were no diet‐related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat‐enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat‐enriched diet compared with standard dietary advice.

Conclusion The oat‐enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes.
Original languageEnglish
Pages (from-to)1314-1323
Number of pages10
JournalDiabetic Medicine
Issue number11
Early online date22 Jun 2013
Publication statusPublished - Nov 2013


ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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