A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes

S. C. Mcgeoch*, A. M. Johnstone, G. E. Lobley, J. Adamson, K. Hickson, G. Holtrop, C. Fyfe, L. F. Clark, D. W. M. Pearson, P. Abraham, I. L. Megson, S. M. Macrury

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat‐enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice.
Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8‐week periods following either the oat‐enriched diet or re‐enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3‐h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high‐sensitivity C‐reactive protein, interleukin 6, interleukin 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.
Results There were no diet‐related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat‐enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat‐enriched diet compared with standard dietary advice.

Conclusion The oat‐enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes.
Original languageEnglish
Pages (from-to)1314-1323
Number of pages10
JournalDiabetic Medicine
Volume30
Issue number11
Early online date22 Jun 2013
DOIs
Publication statusPublished - Nov 2013

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Cross-Over Studies
Type 2 Diabetes Mellitus
Oxidative Stress
Diet
Inflammation
Lipids
Volunteers
Adiponectin
Meals
Life Style
Postprandial Period
Isoprostanes
Interleukin-18
Thiobarbituric Acid Reactive Substances
Avena
Interleukin-6
Fasting
Reactive Oxygen Species
Necrosis
Antioxidants

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes. / Mcgeoch, S. C.; Johnstone, A. M.; Lobley, G. E.; Adamson, J.; Hickson, K.; Holtrop, G.; Fyfe, C.; Clark, L. F.; Pearson, D. W. M.; Abraham, P.; Megson, I. L.; Macrury, S. M.

In: Diabetic Medicine, Vol. 30, No. 11, 11.2013, p. 1314-1323.

Research output: Contribution to journalArticle

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title = "A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes",
abstract = "Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat‐enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice.Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8‐week periods following either the oat‐enriched diet or re‐enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3‐h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high‐sensitivity C‐reactive protein, interleukin 6, interleukin 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.Results There were no diet‐related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat‐enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat‐enriched diet compared with standard dietary advice.Conclusion The oat‐enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes.",
author = "Mcgeoch, {S. C.} and Johnstone, {A. M.} and Lobley, {G. E.} and J. Adamson and K. Hickson and G. Holtrop and C. Fyfe and Clark, {L. F.} and Pearson, {D. W. M.} and P. Abraham and Megson, {I. L.} and Macrury, {S. M.}",
note = "Acknowledgements Partial funding for this study was provided by a grant from the Chief Scientist Office of the Scottish Government (awarded to SCM, AMJ, GEL, DWMP, PA, ILM and SMM). Additional support came from the Rowett Institute of Nutrition and Health, University of Aberdeen, through the core grant provided by Rural and Environment Science and Analytical Services (RESAS), Scottish Government. We would like to thank all the volunteers who participated in this study, as well as Sylvia Hay (Human Nutrition Unit, Rowett Institute of Nurtion and Health) and Fiona Barrett (Clinical Research Facility, University of Highlands and Islands).",
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T1 - A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes

AU - Mcgeoch, S. C.

AU - Johnstone, A. M.

AU - Lobley, G. E.

AU - Adamson, J.

AU - Hickson, K.

AU - Holtrop, G.

AU - Fyfe, C.

AU - Clark, L. F.

AU - Pearson, D. W. M.

AU - Abraham, P.

AU - Megson, I. L.

AU - Macrury, S. M.

N1 - Acknowledgements Partial funding for this study was provided by a grant from the Chief Scientist Office of the Scottish Government (awarded to SCM, AMJ, GEL, DWMP, PA, ILM and SMM). Additional support came from the Rowett Institute of Nutrition and Health, University of Aberdeen, through the core grant provided by Rural and Environment Science and Analytical Services (RESAS), Scottish Government. We would like to thank all the volunteers who participated in this study, as well as Sylvia Hay (Human Nutrition Unit, Rowett Institute of Nurtion and Health) and Fiona Barrett (Clinical Research Facility, University of Highlands and Islands).

PY - 2013/11

Y1 - 2013/11

N2 - Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat‐enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice.Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8‐week periods following either the oat‐enriched diet or re‐enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3‐h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high‐sensitivity C‐reactive protein, interleukin 6, interleukin 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.Results There were no diet‐related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat‐enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat‐enriched diet compared with standard dietary advice.Conclusion The oat‐enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes.

AB - Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat‐enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice.Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8‐week periods following either the oat‐enriched diet or re‐enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3‐h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high‐sensitivity C‐reactive protein, interleukin 6, interleukin 18, tumour necrosis factor‐alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.Results There were no diet‐related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat‐enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat‐enriched diet compared with standard dietary advice.Conclusion The oat‐enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes.

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JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

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