A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Konstantin Schwarz; Satnam Singh; Satish Kumar Parasuraman; Margaret Bruce; Lee Shepstone; Martin Feelisch; Magdalena Minnion; Shakil Ahmad; John Horowitz; Dana K Dawson; Michael P Frenneaux

doi:10.2217/fca-2016-0026

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Konstantin Schwarz, Satnam Singh, Satish Kumar Parasuraman, Margaret Bruce, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, John Horowitz, Dana K Dawson, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Original language	English
Pages (from-to)	617-626
Number of pages	10
Journal	Future cardiology
Volume	12
Issue number	6
Early online date	12 Oct 2016
DOIs	https://doi.org/10.2217/fca-2016-0026
Publication status	Published - Nov 2016

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abstract = "In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.",

author = "Konstantin Schwarz and Satnam Singh and Parasuraman, {Satish Kumar} and Margaret Bruce and Lee Shepstone and Martin Feelisch and Magdalena Minnion and Shakil Ahmad and John Horowitz and Dawson, {Dana K} and Frenneaux, {Michael P}",

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AU - Feelisch, Martin

AU - Minnion, Magdalena

AU - Ahmad, Shakil

AU - Horowitz, John

AU - Dawson, Dana K

AU - Frenneaux, Michael P

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AB - In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

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A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Abstract

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