A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance

Diane Hatziioanou, Melinda J. Mayer*, Sylvia H. Duncan, Harry J. Flint, Arjan Narbad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
Early online date31 Jul 2013
Publication statusPublished - Oct 2013


  • roseburia faecis
  • bacteriocin-like inhibitory substance (BLIS)
  • firmicutes anaerobe
  • gut microbiota
  • trypsin
  • ruminococcus-gnavus strain
  • lactic-acid bacteria
  • human feces
  • purification
  • microbiota
  • probiotics
  • diversity
  • butyrate
  • health
  • gene

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