Abstract
During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 5-8 |
Number of pages | 4 |
Journal | Anaerobe |
Volume | 23 |
Early online date | 31 Jul 2013 |
DOIs | |
Publication status | Published - Oct 2013 |
Keywords
- roseburia faecis
- bacteriocin-like inhibitory substance (BLIS)
- firmicutes anaerobe
- gut microbiota
- trypsin
- ruminococcus-gnavus strain
- lactic-acid bacteria
- human feces
- purification
- microbiota
- probiotics
- diversity
- butyrate
- health
- gene
Cite this
A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance. / Hatziioanou, Diane; Mayer, Melinda J.; Duncan, Sylvia H.; Flint, Harry J.; Narbad, Arjan.
In: Anaerobe, Vol. 23, 10.2013, p. 5-8.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance
AU - Hatziioanou, Diane
AU - Mayer, Melinda J.
AU - Duncan, Sylvia H.
AU - Flint, Harry J.
AU - Narbad, Arjan
N1 - This work was supported by a Biotechnology and Biological Sciences Research Council studentship grant to DH. SHD and HJF acknowledge support from the Scottish Government RESAS programme.
PY - 2013/10
Y1 - 2013/10
N2 - During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.
AB - During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.
KW - roseburia faecis
KW - bacteriocin-like inhibitory substance (BLIS)
KW - firmicutes anaerobe
KW - gut microbiota
KW - trypsin
KW - ruminococcus-gnavus strain
KW - lactic-acid bacteria
KW - human feces
KW - purification
KW - microbiota
KW - probiotics
KW - diversity
KW - butyrate
KW - health
KW - gene
U2 - 10.1016/j.anaerobe.2013.07.006
DO - 10.1016/j.anaerobe.2013.07.006
M3 - Article
VL - 23
SP - 5
EP - 8
JO - Anaerobe
JF - Anaerobe
SN - 1075-9964
ER -