A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

Dan Chen, Therese Truong, Valerie Gaborieau, Graham Byrnes, Amelie Chabrier, Shu-chun Chuang, Andrew F Olshan, Mark C Weissler, Jingchun Luo, Marjorie Romkes, Shama Buch, Tomoko Nukui, Silvia Franceschi, Rolando Herrero, Renato Talamini, Karl T Kelsey, Brock Christensen, Michael D McClean, Martin Lacko, Johannes J Manni & 48 others Wilbert H M Peters, Jan Lubiński, Joanna Trubicka, Marcin Lener, Joshua E Muscat, Philip Lazarus, Qingyi Wei, Erich M Sturgis, Zuo-Feng Zhang, Shen-Chih Chang, Renyi Wang, Stephen M Schwartz, Chu Chen, Simone Benhamou, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana MacFarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf-Neto, Leticia Fernandez, Stefania Boccia, Mia Hashibe, Richard B Hayes, Paolo Boffetta, Paul Brennan, James D McKay

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).

METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies.

RESULTS: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86).

CONCLUSIONS: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.

IMPACT: Further research is warranted to elucidate the mechanisms underlying these observations.

Original languageEnglish
Pages (from-to)658-664
Number of pages7
JournalCancer Epidemiology, Biomarkers and Prevention
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Sex Characteristics
Neoplasms
Hypopharynx
Oropharynx
Mouth Neoplasms
Head and Neck Neoplasms
Larynx
Smoke
Tobacco Products
Esophagus
Mouth
Case-Control Studies
Lung Neoplasms
Epidemiology
Smoking
Research

Keywords

  • aged
  • aged, 80 and over
  • Americas
  • case-control studies
  • chromosomes, human, pair 15
  • Europe
  • female
  • genotype
  • head and neck neoplasms
  • humans
  • male
  • middle aged
  • sex factors
  • smoking

Cite this

Chen, D., Truong, T., Gaborieau, V., Byrnes, G., Chabrier, A., Chuang, S., ... McKay, J. D. (2011). A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiology, Biomarkers and Prevention, 20(4), 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. / Chen, Dan; Truong, Therese; Gaborieau, Valerie; Byrnes, Graham; Chabrier, Amelie; Chuang, Shu-chun; Olshan, Andrew F; Weissler, Mark C; Luo, Jingchun; Romkes, Marjorie; Buch, Shama; Nukui, Tomoko; Franceschi, Silvia; Herrero, Rolando; Talamini, Renato; Kelsey, Karl T; Christensen, Brock; McClean, Michael D; Lacko, Martin; Manni, Johannes J; Peters, Wilbert H M; Lubiński, Jan; Trubicka, Joanna; Lener, Marcin; Muscat, Joshua E; Lazarus, Philip; Wei, Qingyi; Sturgis, Erich M; Zhang, Zuo-Feng; Chang, Shen-Chih; Wang, Renyi; Schwartz, Stephen M; Chen, Chu; Benhamou, Simone; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsagué, Xavier; MacFarlane, Tatiana; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S; Conway, David I; Znaor, Ariana; Healy, Claire M; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Fabianova, Eleonora; Bucur, Alexandru; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Victor; Eluf-Neto, José; Fernandez, Leticia; Boccia, Stefania; Hashibe, Mia; Hayes, Richard B; Boffetta, Paolo; Brennan, Paul; McKay, James D.

In: Cancer Epidemiology, Biomarkers and Prevention, Vol. 20, No. 4, 04.2011, p. 658-664.

Research output: Contribution to journalArticle

Chen, D, Truong, T, Gaborieau, V, Byrnes, G, Chabrier, A, Chuang, S, Olshan, AF, Weissler, MC, Luo, J, Romkes, M, Buch, S, Nukui, T, Franceschi, S, Herrero, R, Talamini, R, Kelsey, KT, Christensen, B, McClean, MD, Lacko, M, Manni, JJ, Peters, WHM, Lubiński, J, Trubicka, J, Lener, M, Muscat, JE, Lazarus, P, Wei, Q, Sturgis, EM, Zhang, Z-F, Chang, S-C, Wang, R, Schwartz, SM, Chen, C, Benhamou, S, Lagiou, P, Holcátová, I, Richiardi, L, Kjaerheim, K, Agudo, A, Castellsagué, X, MacFarlane, T, Barzan, L, Canova, C, Thakker, NS, Conway, DI, Znaor, A, Healy, CM, Ahrens, W, Zaridze, D, Szeszenia-Dabrowska, N, Lissowska, J, Fabianova, E, Bucur, A, Bencko, V, Foretova, L, Janout, V, Curado, MP, Koifman, S, Menezes, A, Wünsch-Filho, V, Eluf-Neto, J, Fernandez, L, Boccia, S, Hashibe, M, Hayes, RB, Boffetta, P, Brennan, P & McKay, JD 2011, 'A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers', Cancer Epidemiology, Biomarkers and Prevention, vol. 20, no. 4, pp. 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008
Chen, Dan ; Truong, Therese ; Gaborieau, Valerie ; Byrnes, Graham ; Chabrier, Amelie ; Chuang, Shu-chun ; Olshan, Andrew F ; Weissler, Mark C ; Luo, Jingchun ; Romkes, Marjorie ; Buch, Shama ; Nukui, Tomoko ; Franceschi, Silvia ; Herrero, Rolando ; Talamini, Renato ; Kelsey, Karl T ; Christensen, Brock ; McClean, Michael D ; Lacko, Martin ; Manni, Johannes J ; Peters, Wilbert H M ; Lubiński, Jan ; Trubicka, Joanna ; Lener, Marcin ; Muscat, Joshua E ; Lazarus, Philip ; Wei, Qingyi ; Sturgis, Erich M ; Zhang, Zuo-Feng ; Chang, Shen-Chih ; Wang, Renyi ; Schwartz, Stephen M ; Chen, Chu ; Benhamou, Simone ; Lagiou, Pagona ; Holcátová, Ivana ; Richiardi, Lorenzo ; Kjaerheim, Kristina ; Agudo, Antonio ; Castellsagué, Xavier ; MacFarlane, Tatiana ; Barzan, Luigi ; Canova, Cristina ; Thakker, Nalin S ; Conway, David I ; Znaor, Ariana ; Healy, Claire M ; Ahrens, Wolfgang ; Zaridze, David ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Fabianova, Eleonora ; Bucur, Alexandru ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Curado, Maria Paula ; Koifman, Sergio ; Menezes, Ana ; Wünsch-Filho, Victor ; Eluf-Neto, José ; Fernandez, Leticia ; Boccia, Stefania ; Hashibe, Mia ; Hayes, Richard B ; Boffetta, Paolo ; Brennan, Paul ; McKay, James D. / A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. In: Cancer Epidemiology, Biomarkers and Prevention. 2011 ; Vol. 20, No. 4. pp. 658-664.
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abstract = "BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies.RESULTS: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95{\%} CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95{\%} CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95{\%} CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95{\%} CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86).CONCLUSIONS: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.IMPACT: Further research is warranted to elucidate the mechanisms underlying these observations.",
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TY - JOUR

T1 - A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

AU - Chen, Dan

AU - Truong, Therese

AU - Gaborieau, Valerie

AU - Byrnes, Graham

AU - Chabrier, Amelie

AU - Chuang, Shu-chun

AU - Olshan, Andrew F

AU - Weissler, Mark C

AU - Luo, Jingchun

AU - Romkes, Marjorie

AU - Buch, Shama

AU - Nukui, Tomoko

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Talamini, Renato

AU - Kelsey, Karl T

AU - Christensen, Brock

AU - McClean, Michael D

AU - Lacko, Martin

AU - Manni, Johannes J

AU - Peters, Wilbert H M

AU - Lubiński, Jan

AU - Trubicka, Joanna

AU - Lener, Marcin

AU - Muscat, Joshua E

AU - Lazarus, Philip

AU - Wei, Qingyi

AU - Sturgis, Erich M

AU - Zhang, Zuo-Feng

AU - Chang, Shen-Chih

AU - Wang, Renyi

AU - Schwartz, Stephen M

AU - Chen, Chu

AU - Benhamou, Simone

AU - Lagiou, Pagona

AU - Holcátová, Ivana

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Agudo, Antonio

AU - Castellsagué, Xavier

AU - MacFarlane, Tatiana

AU - Barzan, Luigi

AU - Canova, Cristina

AU - Thakker, Nalin S

AU - Conway, David I

AU - Znaor, Ariana

AU - Healy, Claire M

AU - Ahrens, Wolfgang

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Bucur, Alexandru

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Curado, Maria Paula

AU - Koifman, Sergio

AU - Menezes, Ana

AU - Wünsch-Filho, Victor

AU - Eluf-Neto, José

AU - Fernandez, Leticia

AU - Boccia, Stefania

AU - Hashibe, Mia

AU - Hayes, Richard B

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - McKay, James D

PY - 2011/4

Y1 - 2011/4

N2 - BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies.RESULTS: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86).CONCLUSIONS: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.IMPACT: Further research is warranted to elucidate the mechanisms underlying these observations.

AB - BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies.RESULTS: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86).CONCLUSIONS: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.IMPACT: Further research is warranted to elucidate the mechanisms underlying these observations.

KW - aged

KW - aged, 80 and over

KW - Americas

KW - case-control studies

KW - chromosomes, human, pair 15

KW - Europe

KW - female

KW - genotype

KW - head and neck neoplasms

KW - humans

KW - male

KW - middle aged

KW - sex factors

KW - smoking

U2 - 10.1158/1055-9965.EPI-10-1008

DO - 10.1158/1055-9965.EPI-10-1008

M3 - Article

VL - 20

SP - 658

EP - 664

JO - Cancer Epidemiology, Biomarkers and Prevention

JF - Cancer Epidemiology, Biomarkers and Prevention

SN - 1055-9965

IS - 4

ER -