A Simple Model to Identify Risk of Sarcopenia and Physical Disability in HIV-Infected Patients

Paulo Farinatti; Lorena Paes; Elizabeth A. Harris; Gabriella O. Lopes; Juliana P. Borges

doi:10.1519/JSC.0000000000002070

A Simple Model to Identify Risk of Sarcopenia and Physical Disability in HIV-Infected Patients

Paulo Farinatti^*, Lorena Paes, Elizabeth A. Harris, Gabriella O. Lopes, Juliana P. Borges

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A simple model to identify risk of sarcopenia and physical disability in HIV-infected patients. J Strength Cond Res 31(9): 2542-2551, 2017 - Early detection of sarcopenia might help preventing muscle loss and disability in HIV-infected patients. This study proposed a model for estimating appendicular skeletal muscle mass (ASM) to calculate indices to identify "sarcopenia" (SA) and "risk for disability due to sarcopenia" (RSA) in patients with HIV. An equation to estimate ASM was developed in 56 patients (47.2 ± 6.9 years), with a cross-validation sample of 24 patients (48.1 ± 6.6 years). The model validity was determined by calculating, in both samples: (a) Concordance between actual vs. estimated ASM; (b) Correlations between actual/estimated ASM vs. peak torque (PT) and total work (TW) during isokinetic knee extension/flexion; (c) Agreement of patients classified with SA and RSA. The predictive equation was ASM (kg) = 7.77 (sex; F = 0/M = 1) + 0.26 (arm circumference; cm) + 0.38 (thigh circumference; cm) + 0.03 (Body Mass Index; kg·m -2) - 8.94 (R 2 = 0.74; R 2 adj = 0.72; SEE = 3.13 kg). Agreement between actual vs. estimated ASM was confirmed in validation (t = 0.081/p = 0.94; R = 0.86/p < 0.0001) and cross-validation (t = 0.12/p = 0.92; R = 0.87/p < 0.0001) samples. Regression characteristics in cross-validation sample (R 2 adj = 0.80; SEE = 3.65) and PRESS (R 2 PRESS = 0.69; SEE PRESS = 3.35) were compatible with the original model. Percent agreements for the classification of SA and RSA from indices calculated using actual and estimated ASM were of 87.5% and 77.2% (gamma correlations 0.72-1.0; p < 0.04) in validation, and 95.8% and 75.0% (gamma correlations 0.98-0.97; p < 0.001) in cross-validation sample, respectively. Correlations between actual/estimated ASM vs. PT (range 0.50-0.73, p ≤ 0.05) and TW (range 0.59-0.74, p ≤ 0.05) were similar in both samples. In conclusion, our model correctly estimated ASM to determine indices for identifying SA and RSA in HIV-infected patients.

Original language	English
Pages (from-to)	2542-2551
Number of pages	10
Journal	Journal of Strength and Conditioning Research
Volume	31
Issue number	9
DOIs	https://doi.org/10.1519/JSC.0000000000002070
Publication status	Published - 1 Sept 2017

Bibliographical note

Funding Information:
This study has been partially funded by grants from the Brazilian Council for Scientific and Technological Development (CNPq, process 479086/2010-9). The authors thank the Interdisciplinary Nutritional Assessment Laboratory of the University of Rio de Janeiro State (LIAN) for performing the DXA exams.

Publisher Copyright:
© 2017 National Strength and Conditioning Association.

Keywords

AIDS
appendicular skeletal muscle mass
isokinetic strength testing
muscle function

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1519/JSC.0000000000002070

Cite this

@article{8ef23eb4228249fcab32e5506e5c388f,

title = "A Simple Model to Identify Risk of Sarcopenia and Physical Disability in HIV-Infected Patients",

abstract = "A simple model to identify risk of sarcopenia and physical disability in HIV-infected patients. J Strength Cond Res 31(9): 2542-2551, 2017 - Early detection of sarcopenia might help preventing muscle loss and disability in HIV-infected patients. This study proposed a model for estimating appendicular skeletal muscle mass (ASM) to calculate indices to identify {"}sarcopenia{"} (SA) and {"}risk for disability due to sarcopenia{"} (RSA) in patients with HIV. An equation to estimate ASM was developed in 56 patients (47.2 ± 6.9 years), with a cross-validation sample of 24 patients (48.1 ± 6.6 years). The model validity was determined by calculating, in both samples: (a) Concordance between actual vs. estimated ASM; (b) Correlations between actual/estimated ASM vs. peak torque (PT) and total work (TW) during isokinetic knee extension/flexion; (c) Agreement of patients classified with SA and RSA. The predictive equation was ASM (kg) = 7.77 (sex; F = 0/M = 1) + 0.26 (arm circumference; cm) + 0.38 (thigh circumference; cm) + 0.03 (Body Mass Index; kg·m -2) - 8.94 (R 2 = 0.74; R 2 adj = 0.72; SEE = 3.13 kg). Agreement between actual vs. estimated ASM was confirmed in validation (t = 0.081/p = 0.94; R = 0.86/p < 0.0001) and cross-validation (t = 0.12/p = 0.92; R = 0.87/p < 0.0001) samples. Regression characteristics in cross-validation sample (R 2 adj = 0.80; SEE = 3.65) and PRESS (R 2 PRESS = 0.69; SEE PRESS = 3.35) were compatible with the original model. Percent agreements for the classification of SA and RSA from indices calculated using actual and estimated ASM were of 87.5% and 77.2% (gamma correlations 0.72-1.0; p < 0.04) in validation, and 95.8% and 75.0% (gamma correlations 0.98-0.97; p < 0.001) in cross-validation sample, respectively. Correlations between actual/estimated ASM vs. PT (range 0.50-0.73, p ≤ 0.05) and TW (range 0.59-0.74, p ≤ 0.05) were similar in both samples. In conclusion, our model correctly estimated ASM to determine indices for identifying SA and RSA in HIV-infected patients.",

keywords = "AIDS, appendicular skeletal muscle mass, isokinetic strength testing, muscle function",

author = "Paulo Farinatti and Lorena Paes and Harris, {Elizabeth A.} and Lopes, {Gabriella O.} and Borges, {Juliana P.}",

note = "Funding Information: This study has been partially funded by grants from the Brazilian Council for Scientific and Technological Development (CNPq, process 479086/2010-9). The authors thank the Interdisciplinary Nutritional Assessment Laboratory of the University of Rio de Janeiro State (LIAN) for performing the DXA exams. Publisher Copyright: {\textcopyright} 2017 National Strength and Conditioning Association.",

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doi = "10.1519/JSC.0000000000002070",

language = "English",

volume = "31",

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T1 - A Simple Model to Identify Risk of Sarcopenia and Physical Disability in HIV-Infected Patients

AU - Farinatti, Paulo

AU - Paes, Lorena

AU - Harris, Elizabeth A.

AU - Lopes, Gabriella O.

AU - Borges, Juliana P.

N1 - Funding Information: This study has been partially funded by grants from the Brazilian Council for Scientific and Technological Development (CNPq, process 479086/2010-9). The authors thank the Interdisciplinary Nutritional Assessment Laboratory of the University of Rio de Janeiro State (LIAN) for performing the DXA exams. Publisher Copyright: © 2017 National Strength and Conditioning Association.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - A simple model to identify risk of sarcopenia and physical disability in HIV-infected patients. J Strength Cond Res 31(9): 2542-2551, 2017 - Early detection of sarcopenia might help preventing muscle loss and disability in HIV-infected patients. This study proposed a model for estimating appendicular skeletal muscle mass (ASM) to calculate indices to identify "sarcopenia" (SA) and "risk for disability due to sarcopenia" (RSA) in patients with HIV. An equation to estimate ASM was developed in 56 patients (47.2 ± 6.9 years), with a cross-validation sample of 24 patients (48.1 ± 6.6 years). The model validity was determined by calculating, in both samples: (a) Concordance between actual vs. estimated ASM; (b) Correlations between actual/estimated ASM vs. peak torque (PT) and total work (TW) during isokinetic knee extension/flexion; (c) Agreement of patients classified with SA and RSA. The predictive equation was ASM (kg) = 7.77 (sex; F = 0/M = 1) + 0.26 (arm circumference; cm) + 0.38 (thigh circumference; cm) + 0.03 (Body Mass Index; kg·m -2) - 8.94 (R 2 = 0.74; R 2 adj = 0.72; SEE = 3.13 kg). Agreement between actual vs. estimated ASM was confirmed in validation (t = 0.081/p = 0.94; R = 0.86/p < 0.0001) and cross-validation (t = 0.12/p = 0.92; R = 0.87/p < 0.0001) samples. Regression characteristics in cross-validation sample (R 2 adj = 0.80; SEE = 3.65) and PRESS (R 2 PRESS = 0.69; SEE PRESS = 3.35) were compatible with the original model. Percent agreements for the classification of SA and RSA from indices calculated using actual and estimated ASM were of 87.5% and 77.2% (gamma correlations 0.72-1.0; p < 0.04) in validation, and 95.8% and 75.0% (gamma correlations 0.98-0.97; p < 0.001) in cross-validation sample, respectively. Correlations between actual/estimated ASM vs. PT (range 0.50-0.73, p ≤ 0.05) and TW (range 0.59-0.74, p ≤ 0.05) were similar in both samples. In conclusion, our model correctly estimated ASM to determine indices for identifying SA and RSA in HIV-infected patients.

AB - A simple model to identify risk of sarcopenia and physical disability in HIV-infected patients. J Strength Cond Res 31(9): 2542-2551, 2017 - Early detection of sarcopenia might help preventing muscle loss and disability in HIV-infected patients. This study proposed a model for estimating appendicular skeletal muscle mass (ASM) to calculate indices to identify "sarcopenia" (SA) and "risk for disability due to sarcopenia" (RSA) in patients with HIV. An equation to estimate ASM was developed in 56 patients (47.2 ± 6.9 years), with a cross-validation sample of 24 patients (48.1 ± 6.6 years). The model validity was determined by calculating, in both samples: (a) Concordance between actual vs. estimated ASM; (b) Correlations between actual/estimated ASM vs. peak torque (PT) and total work (TW) during isokinetic knee extension/flexion; (c) Agreement of patients classified with SA and RSA. The predictive equation was ASM (kg) = 7.77 (sex; F = 0/M = 1) + 0.26 (arm circumference; cm) + 0.38 (thigh circumference; cm) + 0.03 (Body Mass Index; kg·m -2) - 8.94 (R 2 = 0.74; R 2 adj = 0.72; SEE = 3.13 kg). Agreement between actual vs. estimated ASM was confirmed in validation (t = 0.081/p = 0.94; R = 0.86/p < 0.0001) and cross-validation (t = 0.12/p = 0.92; R = 0.87/p < 0.0001) samples. Regression characteristics in cross-validation sample (R 2 adj = 0.80; SEE = 3.65) and PRESS (R 2 PRESS = 0.69; SEE PRESS = 3.35) were compatible with the original model. Percent agreements for the classification of SA and RSA from indices calculated using actual and estimated ASM were of 87.5% and 77.2% (gamma correlations 0.72-1.0; p < 0.04) in validation, and 95.8% and 75.0% (gamma correlations 0.98-0.97; p < 0.001) in cross-validation sample, respectively. Correlations between actual/estimated ASM vs. PT (range 0.50-0.73, p ≤ 0.05) and TW (range 0.59-0.74, p ≤ 0.05) were similar in both samples. In conclusion, our model correctly estimated ASM to determine indices for identifying SA and RSA in HIV-infected patients.

KW - AIDS

KW - appendicular skeletal muscle mass

KW - isokinetic strength testing

KW - muscle function

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U2 - 10.1519/JSC.0000000000002070

DO - 10.1519/JSC.0000000000002070

M3 - Article

C2 - 28658070

AN - SCOPUS:85028650720

SN - 1064-8011

VL - 31

SP - 2542

EP - 2551

JO - Journal of Strength and Conditioning Research

JF - Journal of Strength and Conditioning Research

IS - 9

ER -

A Simple Model to Identify Risk of Sarcopenia and Physical Disability in HIV-Infected Patients

Abstract

Bibliographical note

Keywords

UN SDGs

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