A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors

A. Grimaldi Alcina, L. A. Stevenson, C. Haj, R. Smoum, R. Mechoulam, J. N. Hislop, R. G. Pertwee

Research output: Contribution to journalAbstractpeer-review


The 5‐HT1Areceptor plays a significant rolein depression, anxiety, nausea, and emesis. Cannabidiolic acid (CBDA),a compound present in cannabis, shows therapeutic potential by act-ing through this receptor, but its low stability impedes its developmentas a medicine.
Original languageEnglish
Article numberOC011
Pages (from-to)3011-3012
Number of pages2
JournalBritish Journal of Pharmacology
Issue number16
Early online date9 Jul 2019
Publication statusPublished - Aug 2019
EventBritish-Pharmacology-Society Meeting (Pharmacology) - London
Duration: 18 Dec 201820 Dec 2018

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