A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements

Ivory Huang, Diane Mak, Prudence Cheung, Miriam Abraham, Tom Clemens, Steve Turner (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

Background
Reduced birth weight is associated with many maternal environmental exposures during pregnancy, but the gestational age at onset of this association is unknown. We have previously reported associations between maternal smoking and fetal size.

Objective
To report on our systematic review of the literature describing associations between antenatal size and growth and maternal exposures during pregnancy.

Data sources
Electronic databases (OVID and EMBASE) and web sites for cohort studies were searched. Study eligibility. Studies were eligible if they examined associations between maternal environmental exposures (including ambient air exposure, diet and alcohol) and antenatal fetal ultrasound measurements. Study appraisal. The Navigation Guide was used to assess the strength of evidence.

Results
There were 451 abstracts identified and 36 papers were included of which maternal diet was the exposure of interest in 15, maternal ambient air exposure in 10, maternal alcohol in 3 and other exposures in 8. The first paper was published in 2006. Associations were present between exposures in 18% of comparisons with second trimester measurements and in 46% of comparisons with third trimester measurements. In the third trimester, when an association was present, reduced head size was most commonly (58%) associated with current or previous maternal exposure, with reduced length being least commonly (32%) associated and reduced weight being intermediate (52%). In the third trimester, increased maternal nitrogen dioxide exposure was associated with reduced head size was associated with in all seven studies identified and reduced fetal weight in five out of six studies.

Conclusion
There is sufficient evidence of toxicity in the context of maternal exposure to nitrogen dioxide and reduced third trimester fetal head size. There is insufficient evidence of toxicity with regard to maternal exposures to dietary factors, alcohol and environmental chemicals and reduced fetal size.
Original languageEnglish
Pages (from-to)528-538
Number of pages11
JournalEnvironmental Research
Volume173
Early online date8 Apr 2019
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Maternal Exposure
smoking
pregnancy
Nitrogen Dioxide
Smoking
Alcohols
Third Pregnancy Trimester
Nutrition
Pregnancy
Mothers
Toxicity
Head
Environmental Exposure
Air
Websites
Navigation
air exposure
alcohol
Ultrasonics
Diet

Keywords

  • air pollution
  • benzene
  • diet
  • ethanol
  • fetus
  • mother
  • Phthalic acids
  • Ethanol
  • Diet
  • Mother
  • Benzene
  • Air pollution
  • Fetus

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements. / Huang, Ivory ; Mak, Diane ; Cheung, Prudence ; Abraham, Miriam; Clemens, Tom ; Turner, Steve (Corresponding Author).

In: Environmental Research, Vol. 173, 06.2019, p. 528-538.

Research output: Contribution to journalArticle

Huang, Ivory ; Mak, Diane ; Cheung, Prudence ; Abraham, Miriam ; Clemens, Tom ; Turner, Steve. / A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements. In: Environmental Research. 2019 ; Vol. 173. pp. 528-538.
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title = "A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements",
abstract = "BackgroundReduced birth weight is associated with many maternal environmental exposures during pregnancy, but the gestational age at onset of this association is unknown. We have previously reported associations between maternal smoking and fetal size.ObjectiveTo report on our systematic review of the literature describing associations between antenatal size and growth and maternal exposures during pregnancy.Data sourcesElectronic databases (OVID and EMBASE) and web sites for cohort studies were searched. Study eligibility. Studies were eligible if they examined associations between maternal environmental exposures (including ambient air exposure, diet and alcohol) and antenatal fetal ultrasound measurements. Study appraisal. The Navigation Guide was used to assess the strength of evidence.ResultsThere were 451 abstracts identified and 36 papers were included of which maternal diet was the exposure of interest in 15, maternal ambient air exposure in 10, maternal alcohol in 3 and other exposures in 8. The first paper was published in 2006. Associations were present between exposures in 18{\%} of comparisons with second trimester measurements and in 46{\%} of comparisons with third trimester measurements. In the third trimester, when an association was present, reduced head size was most commonly (58{\%}) associated with current or previous maternal exposure, with reduced length being least commonly (32{\%}) associated and reduced weight being intermediate (52{\%}). In the third trimester, increased maternal nitrogen dioxide exposure was associated with reduced head size was associated with in all seven studies identified and reduced fetal weight in five out of six studies.ConclusionThere is sufficient evidence of toxicity in the context of maternal exposure to nitrogen dioxide and reduced third trimester fetal head size. There is insufficient evidence of toxicity with regard to maternal exposures to dietary factors, alcohol and environmental chemicals and reduced fetal size.",
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note = "Acknowledgements The authors thank Dr Juleen Lam for her advice on the use of the Navigation guide and for her helpful comments on a draft of the submitted manuscript. Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.",
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T1 - A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements

AU - Huang, Ivory

AU - Mak, Diane

AU - Cheung, Prudence

AU - Abraham, Miriam

AU - Clemens, Tom

AU - Turner, Steve

N1 - Acknowledgements The authors thank Dr Juleen Lam for her advice on the use of the Navigation guide and for her helpful comments on a draft of the submitted manuscript. Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

PY - 2019/6

Y1 - 2019/6

N2 - BackgroundReduced birth weight is associated with many maternal environmental exposures during pregnancy, but the gestational age at onset of this association is unknown. We have previously reported associations between maternal smoking and fetal size.ObjectiveTo report on our systematic review of the literature describing associations between antenatal size and growth and maternal exposures during pregnancy.Data sourcesElectronic databases (OVID and EMBASE) and web sites for cohort studies were searched. Study eligibility. Studies were eligible if they examined associations between maternal environmental exposures (including ambient air exposure, diet and alcohol) and antenatal fetal ultrasound measurements. Study appraisal. The Navigation Guide was used to assess the strength of evidence.ResultsThere were 451 abstracts identified and 36 papers were included of which maternal diet was the exposure of interest in 15, maternal ambient air exposure in 10, maternal alcohol in 3 and other exposures in 8. The first paper was published in 2006. Associations were present between exposures in 18% of comparisons with second trimester measurements and in 46% of comparisons with third trimester measurements. In the third trimester, when an association was present, reduced head size was most commonly (58%) associated with current or previous maternal exposure, with reduced length being least commonly (32%) associated and reduced weight being intermediate (52%). In the third trimester, increased maternal nitrogen dioxide exposure was associated with reduced head size was associated with in all seven studies identified and reduced fetal weight in five out of six studies.ConclusionThere is sufficient evidence of toxicity in the context of maternal exposure to nitrogen dioxide and reduced third trimester fetal head size. There is insufficient evidence of toxicity with regard to maternal exposures to dietary factors, alcohol and environmental chemicals and reduced fetal size.

AB - BackgroundReduced birth weight is associated with many maternal environmental exposures during pregnancy, but the gestational age at onset of this association is unknown. We have previously reported associations between maternal smoking and fetal size.ObjectiveTo report on our systematic review of the literature describing associations between antenatal size and growth and maternal exposures during pregnancy.Data sourcesElectronic databases (OVID and EMBASE) and web sites for cohort studies were searched. Study eligibility. Studies were eligible if they examined associations between maternal environmental exposures (including ambient air exposure, diet and alcohol) and antenatal fetal ultrasound measurements. Study appraisal. The Navigation Guide was used to assess the strength of evidence.ResultsThere were 451 abstracts identified and 36 papers were included of which maternal diet was the exposure of interest in 15, maternal ambient air exposure in 10, maternal alcohol in 3 and other exposures in 8. The first paper was published in 2006. Associations were present between exposures in 18% of comparisons with second trimester measurements and in 46% of comparisons with third trimester measurements. In the third trimester, when an association was present, reduced head size was most commonly (58%) associated with current or previous maternal exposure, with reduced length being least commonly (32%) associated and reduced weight being intermediate (52%). In the third trimester, increased maternal nitrogen dioxide exposure was associated with reduced head size was associated with in all seven studies identified and reduced fetal weight in five out of six studies.ConclusionThere is sufficient evidence of toxicity in the context of maternal exposure to nitrogen dioxide and reduced third trimester fetal head size. There is insufficient evidence of toxicity with regard to maternal exposures to dietary factors, alcohol and environmental chemicals and reduced fetal size.

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KW - diet

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KW - fetus

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KW - Phthalic acids

KW - Ethanol

KW - Diet

KW - Mother

KW - Benzene

KW - Air pollution

KW - Fetus

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