A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Hannah Gautrey, Fergus Nicol, Alan A Sneddon, Judith Hall, John Hesketh

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.
    Original languageEnglish
    Pages (from-to)584-591
    Number of pages8
    JournalBiochimica et Biophysica Acta
    Volume1810
    Issue number6
    Early online date1 Apr 2011
    DOIs
    Publication statusPublished - Jun 2011

    Fingerprint

    Selenoproteins
    Caco-2 Cells
    3' Untranslated Regions
    Cell Survival
    Glutathione Peroxidase
    Transfer RNA
    Single Nucleotide Polymorphism
    Messenger RNA
    Genes

    Keywords

    • 3' Untranslated Regions
    • Caco-2 Cells
    • Cell Survival
    • Gene Expression Regulation, Enzymologic
    • Glutathione Peroxidase
    • Humans
    • Polymorphism, Genetic
    • Reverse Transcriptase Polymerase Chain Reaction
    • Selenium
    • Selenoproteins
    • Trace Elements
    • Transfection

    Cite this

    A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells. / Gautrey, Hannah; Nicol, Fergus; Sneddon, Alan A; Hall, Judith; Hesketh, John.

    In: Biochimica et Biophysica Acta, Vol. 1810, No. 6, 06.2011, p. 584-591.

    Research output: Contribution to journalArticle

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    abstract = "Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.",
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    AU - Nicol, Fergus

    AU - Sneddon, Alan A

    AU - Hall, Judith

    AU - Hesketh, John

    N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

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    KW - Trace Elements

    KW - Transfection

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