A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Hannah Gautrey, Fergus Nicol, Alan A Sneddon, Judith Hall, John Hesketh

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.
    Original languageEnglish
    Pages (from-to)584-591
    Number of pages8
    JournalBiochimica et Biophysica Acta
    Volume1810
    Issue number6
    Early online date1 Apr 2011
    DOIs
    Publication statusPublished - Jun 2011

    Keywords

    • 3' Untranslated Regions
    • Caco-2 Cells
    • Cell Survival
    • Gene Expression Regulation, Enzymologic
    • Glutathione Peroxidase
    • Humans
    • Polymorphism, Genetic
    • Reverse Transcriptase Polymerase Chain Reaction
    • Selenium
    • Selenoproteins
    • Trace Elements
    • Transfection

    Fingerprint Dive into the research topics of 'A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells'. Together they form a unique fingerprint.

    Cite this