A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Hannah Gautrey; Fergus Nicol; Alan A Sneddon; Judith Hall; John Hesketh

doi:10.1016/j.bbagen.2011.03.016

A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Hannah Gautrey, Fergus Nicol, Alan A Sneddon, Judith Hall, John Hesketh

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.

Original language	English
Pages (from-to)	584-591
Number of pages	8
Journal	Biochimica et Biophysica Acta
Volume	1810
Issue number	6
Early online date	1 Apr 2011
DOIs	https://doi.org/10.1016/j.bbagen.2011.03.016
Publication status	Published - Jun 2011

Keywords

3' Untranslated Regions
Caco-2 Cells
Cell Survival
Gene Expression Regulation, Enzymologic
Glutathione Peroxidase
Humans
Polymorphism, Genetic
Reverse Transcriptase Polymerase Chain Reaction
Selenium
Selenoproteins
Trace Elements
Transfection

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10.1016/j.bbagen.2011.03.016

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title = "A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells",

abstract = "Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.",

keywords = "3' Untranslated Regions, Caco-2 Cells, Cell Survival, Gene Expression Regulation, Enzymologic, Glutathione Peroxidase, Humans, Polymorphism, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Selenium, Selenoproteins, Trace Elements, Transfection",

author = "Hannah Gautrey and Fergus Nicol and Sneddon, {Alan A} and Judith Hall and John Hesketh",

year = "2011",

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doi = "10.1016/j.bbagen.2011.03.016",

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pages = "584--591",

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T1 - A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

AU - Gautrey, Hannah

AU - Nicol, Fergus

AU - Sneddon, Alan A

AU - Hall, Judith

AU - Hesketh, John

PY - 2011/6

Y1 - 2011/6

N2 - Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.

AB - Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3'untranslated region (3'UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3'UTR.

KW - 3' Untranslated Regions

KW - Caco-2 Cells

KW - Cell Survival

KW - Gene Expression Regulation, Enzymologic

KW - Glutathione Peroxidase

KW - Humans

KW - Polymorphism, Genetic

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Selenium

KW - Selenoproteins

KW - Trace Elements

KW - Transfection

U2 - 10.1016/j.bbagen.2011.03.016

DO - 10.1016/j.bbagen.2011.03.016

M3 - Article

C2 - 21459128

SN - 0006-3002

VL - 1810

SP - 584

EP - 591

JO - Biochimica et Biophysica Acta

JF - Biochimica et Biophysica Acta

IS - 6

ER -

A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

Abstract

Keywords

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