A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths

Pierre Boudinot, Jun Zou, Tatsuya Ota, Francesco Buonocore, Giuseppe Scapigliati, Adriana Canapa, John Cannon, Gary Litman, John D. Hansen

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The recent availability of both robust transcriptome and genome resources for coelacanth (Latimeria chalumnae) has led to unique discoveries for coelacanth immunity such as the lack of IgM, a central component of adaptive immunity. This study was designed to more precisely address the origins and evolution of gene families involved in the initial recognition and response to microbial pathogens, which effect innate immunity. Several multigene families involved in innate immunity are addressed, including: Toll-like receptors (TLRs), retinoic acid inducible gene 1 (RIG1)-like receptors (RLRs), the nucleotide-binding domain and leucine-rich repeat containing proteins (NLRs), diverse immunoglobulin domain-containing proteins (DICP) and modular domain immune-type receptors (MDIRs). Our analyses also include the tripartite motif-containing proteins (TRIM), which are involved in pathogen recognition as well as the positive regulation of antiviral immunity. Finally, this study addressed some of the downstream effectors of the antimicrobial response including IL-1 family members, type I and II interferons (IFN) and IFN-stimulated effectors (ISGs). Collectively, the genes and gene families in coelacanth that effect innate immune functions share characteristics both in content, structure and arrangement with those found in tetrapods but not in teleosts. The findings support the sister group relationship of coelacanth fish with tetrapods.
Original languageEnglish
Pages (from-to)415-437
Number of pages23
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume322
Issue number6
Early online date30 Jan 2014
DOIs
Publication statusPublished - Sep 2014

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tetrapod
immunity
interferons
Innate Immunity
gene
Genes
Immunity
genes
protein
Interferon Type I
pathogen
receptors
proteins
pathogens
Toll-Like Receptors
retinoic acid
interleukin-1
Adaptive Immunity
Multigene Family
Tretinoin

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A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths. / Boudinot, Pierre; Zou, Jun; Ota, Tatsuya; Buonocore, Francesco; Scapigliati, Giuseppe; Canapa, Adriana ; Cannon, John; Litman, Gary; Hansen, John D.

In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Vol. 322, No. 6, 09.2014, p. 415-437.

Research output: Contribution to journalArticle

Boudinot, P, Zou, J, Ota, T, Buonocore, F, Scapigliati, G, Canapa, A, Cannon, J, Litman, G & Hansen, JD 2014, 'A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths', Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol. 322, no. 6, pp. 415-437. https://doi.org/10.1002/jez.b.22559
Boudinot, Pierre ; Zou, Jun ; Ota, Tatsuya ; Buonocore, Francesco ; Scapigliati, Giuseppe ; Canapa, Adriana ; Cannon, John ; Litman, Gary ; Hansen, John D. / A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths. In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2014 ; Vol. 322, No. 6. pp. 415-437.
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