Acanthomine A, a new pyrimidine-ß-carboline alkaloid from the sponge Acanthostrongylophora ingens

S.R.M. Ibrahim, R. Ebel, P. Proksch

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Chemical investigation of the ethyl acetate extract of the sponge Acanthostrongylophora ingens afford one new pyrimidine-ß-carboline alkaloid named acanthomine A (2), together with two known compounds annomontine (1) and 1,2,3,4-tetrahydronorharman-1-one (3). Their structures were unambiguously established on the basis of NMR spectroscopy (H, C, H-H COSY, HMQC and HMBC) and mass spectrometry. The isolated compounds were tested for cytotoxic activity using brine shrimp bioassay and different cancer cell lines.
Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNatural Product Communications
Volume3
Issue number2
Publication statusPublished - 2008

Keywords

  • Acanthomine A
  • Acanthostrongylophora ingens
  • alkaloids
  • cytotoxic activity
  • Pyrimidine-ß-carboline

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