Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer

Jean Winter; Graeme P Young; Ying Hu; Silvia W Gratz; Michael A Conlon; Richard K Le Leu

doi:10.1002/mnfr.201300430

Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer

Jean Winter, Graeme P Young, Ying Hu, Silvia W Gratz, Michael A Conlon, Richard K Le Leu

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies demonstrating protective effects against CRC. By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects.

Original language	English
Pages (from-to)	550-558
Number of pages	9
Journal	Molecular Nutrition & Food Research
Volume	58
Issue number	3
Early online date	1 Oct 2013
DOIs	https://doi.org/10.1002/mnfr.201300430
Publication status	Published - Mar 2014

Keywords

heme
8-hydroxy-2-deoxyguanosine
O6-Methyl-2-deoxyguanosine
red meat
resistant starch

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mnfr.201300430

Silvia Gratz
- School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Senior Research Fellow
Person: Academic Related - Research

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Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer. / Winter, Jean; Young, Graeme P; Hu, Ying et al.

In: Molecular Nutrition & Food Research, Vol. 58, No. 3, 03.2014, p. 550-558.

Research output: Contribution to journal › Article › peer-review

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abstract = "Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies demonstrating protective effects against CRC. By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects.",

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author = "Jean Winter and Young, {Graeme P} and Ying Hu and Gratz, {Silvia W} and Conlon, {Michael A} and {Le Leu}, {Richard K}",

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AU - Le Leu, Richard K

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KW - O6-Methyl-2-deoxyguanosine

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Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer

Abstract

Keywords

UN SDGs

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Silvia Gratz

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