Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies demonstrating protective effects against CRC. By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects.
- red meat
- resistant starch
Winter, J., Young, G. P., Hu, Y., Gratz, S. W., Conlon, M. A., & Le Leu, R. K. (2014). Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer. Molecular Nutrition & Food Research, 58(3), 550-558. https://doi.org/10.1002/mnfr.201300430