Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation

R J Shaw, G M Walsh, O Cromwell, R Moqbel, C J Spry, A B Kay

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Eosinophils, a class of granular leukocytes, are prominent in many inflammatory processes, particularly in asthma, certain allergic diseases and during infections with helminthic parasites. Following incubation with the Ca ionophore A23187 (refs 1-4) (a non-physiological agent which circumvents membrane calcium-gating mechanisms), eosinophils generate large amounts of sulphidopeptide leukotrienes, potent inducers of smooth muscle constriction and mucus production. These are now known to represent the activity previously termed 'slow-reacting substance of anaphylaxis' (SRS-A) but attempts to identify a physiological stimulus for SRS-A production by eosinophils have so far been unsuccessful. The cells contain recognized receptors for IgG (Fc) and it is known that they adhere to, and can be activated by, contact with the surface of large organisms such as helminthic larvae. We show here that eosinophils, particularly when activated, produce sulphidopeptide leukotrienes after contact with large particles coated with IgG.
Original languageEnglish
Pages (from-to)150-152
Number of pages3
JournalNature
Volume316
Issue number6024
DOIs
Publication statusPublished - 11 Jul 1985

Cite this

Shaw, R. J., Walsh, G. M., Cromwell, O., Moqbel, R., Spry, C. J., & Kay, A. B. (1985). Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation. Nature, 316(6024), 150-152. https://doi.org/10.1038/316150a0

Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation. / Shaw, R J ; Walsh, G M; Cromwell, O ; Moqbel, R ; Spry, C J; Kay, A B .

In: Nature, Vol. 316, No. 6024, 11.07.1985, p. 150-152.

Research output: Contribution to journalArticle

Shaw, RJ, Walsh, GM, Cromwell, O, Moqbel, R, Spry, CJ & Kay, AB 1985, 'Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation', Nature, vol. 316, no. 6024, pp. 150-152. https://doi.org/10.1038/316150a0
Shaw, R J ; Walsh, G M ; Cromwell, O ; Moqbel, R ; Spry, C J ; Kay, A B . / Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation. In: Nature. 1985 ; Vol. 316, No. 6024. pp. 150-152.
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