Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

D S  Ugdyzhekova; A V  Krylatov; N A  Bernatskaya; L N  Maslov; R  Mechoulam; R G  Pertwee

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

D S Ugdyzhekova, A V Krylatov, N A Bernatskaya, L N Maslov, R Mechoulam, R G Pertwee

Medical Sciences

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Abstract

We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

Original language	English
Pages (from-to)	125-126
Number of pages	2
Journal	Bulletin of Experimental Biology and Medicine
Volume	133
Publication status	Published - 2002

Keywords

cannabinoid receptors
myocardial infarction

Cite this

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title = "Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis",

abstract = "We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.",

keywords = "cannabinoid receptors, myocardial infarction",

author = "Ugdyzhekova, {D S} and Krylatov, {A V} and Bernatskaya, {N A} and Maslov, {L N} and R Mechoulam and Pertwee, {R G}",

year = "2002",

language = "English",

volume = "133",

pages = "125--126",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "1573-8221",

publisher = "Springer New York",

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TY - JOUR

T1 - Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

AU - Ugdyzhekova, D S

AU - Krylatov, A V

AU - Bernatskaya, N A

AU - Maslov, L N

AU - Mechoulam, R

AU - Pertwee, R G

PY - 2002

Y1 - 2002

N2 - We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

AB - We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

KW - cannabinoid receptors

KW - myocardial infarction

M3 - Article

SN - 1573-8221

VL - 133

SP - 125

EP - 126

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

ER -

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

Abstract

Keywords

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