Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

K M Baeten, M C Richard, S M Kanse, Nicola Jane Mutch, J L Degen, N A Booth

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.
Original languageEnglish
Pages (from-to)1313-1322
Number of pages10
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number6
Early online date17 Feb 2010
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Blood Platelets
  • Blotting, Western
  • Enzyme Activation
  • Enzyme-Linked Immunosorbent Assay
  • Fibrinolysis
  • Humans
  • Plasminogen
  • Urokinase-Type Plasminogen Activator

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