Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

K M Baeten, M C Richard, S M Kanse, Nicola Jane Mutch, J L Degen, N A Booth

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.
Original languageEnglish
Pages (from-to)1313-1322
Number of pages10
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number6
Early online date17 Feb 2010
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Plasminogen
Urokinase-Type Plasminogen Activator
Fibrinolysis
Blood Platelets
Tissue Plasminogen Activator
Hemostasis

Keywords

  • Blood Platelets
  • Blotting, Western
  • Enzyme Activation
  • Enzyme-Linked Immunosorbent Assay
  • Fibrinolysis
  • Humans
  • Plasminogen
  • Urokinase-Type Plasminogen Activator

Cite this

@article{9557371b97254410abed734e7c690ee2,
title = "Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets",
abstract = "Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.",
keywords = "Blood Platelets, Blotting, Western, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Fibrinolysis, Humans, Plasminogen, Urokinase-Type Plasminogen Activator",
author = "Baeten, {K M} and Richard, {M C} and Kanse, {S M} and Mutch, {Nicola Jane} and Degen, {J L} and Booth, {N A}",
year = "2010",
month = "6",
doi = "10.1111/j.1538-7836.2010.03813.x",
language = "English",
volume = "8",
pages = "1313--1322",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen

T2 - a mechanism for stimulation of fibrinolysis by platelets

AU - Baeten, K M

AU - Richard, M C

AU - Kanse, S M

AU - Mutch, Nicola Jane

AU - Degen, J L

AU - Booth, N A

PY - 2010/6

Y1 - 2010/6

N2 - Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.

AB - Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.

KW - Blood Platelets

KW - Blotting, Western

KW - Enzyme Activation

KW - Enzyme-Linked Immunosorbent Assay

KW - Fibrinolysis

KW - Humans

KW - Plasminogen

KW - Urokinase-Type Plasminogen Activator

U2 - 10.1111/j.1538-7836.2010.03813.x

DO - 10.1111/j.1538-7836.2010.03813.x

M3 - Article

VL - 8

SP - 1313

EP - 1322

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 6

ER -