ACUTE EFFECTS OF CAPTOPRIL ON THE RENAL ACTIONS OF FUROSEMIDE IN PATIENTS WITH CHRONIC HEART-FAILURE

J S MCLAY, J J MCMURRAY, A B BRIDGES, C G FRASER, A D STRUTHERS

Research output: Contribution to journalArticle

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Abstract

This study examined the effects of conventional doses of oral captopril on the renal responses to oral furosemide in ambulant patients with stable chronic heart failure. Twenty-five men (mean age 63 years) were randomized to one of two groups. Group 1 received placebo on days 1 and 2 before furosemide. Group 2 received placebo on day 1 before furosemide and captopril thereafter (i.e., captopril before furosemide on day 2). Urine was collected after either placebo or captopril and after furosemide (taken after placebo or captopril pretreatment). Captopril by itself did not affect renal function. Captopril did, however, significantly affect the renal response to furosemide. The increase in urine flow rate after furosemide in group 2 was decreased from 225% with placebo to 128% with captopril (p < 0.02). The increase in sodium excretion after furosemide was decreased from 623% with placebo to 242% with captopril (p < 0.001). Pretreatment with captopril abolished the increase in creatinine clearance after furosemide. The increase in urinary albumin excretion (used as a marker of glomerular function) after furosemide was also significantly blunted by captopril. Conventional doses of captopril acutely inhibit the natriuretic and diuretic responses to furosemide at the glomerular level in ambulant patients with stable chronic heart failure.

Original languageEnglish
Pages (from-to)879-886
Number of pages8
JournalAmerican Heart Journal
Volume126
Issue number4
Publication statusPublished - Oct 1993

Keywords

  • ATRIAL NATRIURETIC FACTOR
  • CONVERTING ENZYME-INHIBITION
  • FRUSEMIDE
  • PROSTAGLANDINS
  • COMBINATION
  • EXCRETION
  • RESPONSES
  • WATER

Cite this

MCLAY, J. S., MCMURRAY, J. J., BRIDGES, A. B., FRASER, C. G., & STRUTHERS, A. D. (1993). ACUTE EFFECTS OF CAPTOPRIL ON THE RENAL ACTIONS OF FUROSEMIDE IN PATIENTS WITH CHRONIC HEART-FAILURE. American Heart Journal, 126(4), 879-886.

ACUTE EFFECTS OF CAPTOPRIL ON THE RENAL ACTIONS OF FUROSEMIDE IN PATIENTS WITH CHRONIC HEART-FAILURE. / MCLAY, J S ; MCMURRAY, J J ; BRIDGES, A B ; FRASER, C G ; STRUTHERS, A D .

In: American Heart Journal, Vol. 126, No. 4, 10.1993, p. 879-886.

Research output: Contribution to journalArticle

MCLAY, JS, MCMURRAY, JJ, BRIDGES, AB, FRASER, CG & STRUTHERS, AD 1993, 'ACUTE EFFECTS OF CAPTOPRIL ON THE RENAL ACTIONS OF FUROSEMIDE IN PATIENTS WITH CHRONIC HEART-FAILURE', American Heart Journal, vol. 126, no. 4, pp. 879-886.
MCLAY, J S ; MCMURRAY, J J ; BRIDGES, A B ; FRASER, C G ; STRUTHERS, A D . / ACUTE EFFECTS OF CAPTOPRIL ON THE RENAL ACTIONS OF FUROSEMIDE IN PATIENTS WITH CHRONIC HEART-FAILURE. In: American Heart Journal. 1993 ; Vol. 126, No. 4. pp. 879-886.
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abstract = "This study examined the effects of conventional doses of oral captopril on the renal responses to oral furosemide in ambulant patients with stable chronic heart failure. Twenty-five men (mean age 63 years) were randomized to one of two groups. Group 1 received placebo on days 1 and 2 before furosemide. Group 2 received placebo on day 1 before furosemide and captopril thereafter (i.e., captopril before furosemide on day 2). Urine was collected after either placebo or captopril and after furosemide (taken after placebo or captopril pretreatment). Captopril by itself did not affect renal function. Captopril did, however, significantly affect the renal response to furosemide. The increase in urine flow rate after furosemide in group 2 was decreased from 225{\%} with placebo to 128{\%} with captopril (p < 0.02). The increase in sodium excretion after furosemide was decreased from 623{\%} with placebo to 242{\%} with captopril (p < 0.001). Pretreatment with captopril abolished the increase in creatinine clearance after furosemide. The increase in urinary albumin excretion (used as a marker of glomerular function) after furosemide was also significantly blunted by captopril. Conventional doses of captopril acutely inhibit the natriuretic and diuretic responses to furosemide at the glomerular level in ambulant patients with stable chronic heart failure.",
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N2 - This study examined the effects of conventional doses of oral captopril on the renal responses to oral furosemide in ambulant patients with stable chronic heart failure. Twenty-five men (mean age 63 years) were randomized to one of two groups. Group 1 received placebo on days 1 and 2 before furosemide. Group 2 received placebo on day 1 before furosemide and captopril thereafter (i.e., captopril before furosemide on day 2). Urine was collected after either placebo or captopril and after furosemide (taken after placebo or captopril pretreatment). Captopril by itself did not affect renal function. Captopril did, however, significantly affect the renal response to furosemide. The increase in urine flow rate after furosemide in group 2 was decreased from 225% with placebo to 128% with captopril (p < 0.02). The increase in sodium excretion after furosemide was decreased from 623% with placebo to 242% with captopril (p < 0.001). Pretreatment with captopril abolished the increase in creatinine clearance after furosemide. The increase in urinary albumin excretion (used as a marker of glomerular function) after furosemide was also significantly blunted by captopril. Conventional doses of captopril acutely inhibit the natriuretic and diuretic responses to furosemide at the glomerular level in ambulant patients with stable chronic heart failure.

AB - This study examined the effects of conventional doses of oral captopril on the renal responses to oral furosemide in ambulant patients with stable chronic heart failure. Twenty-five men (mean age 63 years) were randomized to one of two groups. Group 1 received placebo on days 1 and 2 before furosemide. Group 2 received placebo on day 1 before furosemide and captopril thereafter (i.e., captopril before furosemide on day 2). Urine was collected after either placebo or captopril and after furosemide (taken after placebo or captopril pretreatment). Captopril by itself did not affect renal function. Captopril did, however, significantly affect the renal response to furosemide. The increase in urine flow rate after furosemide in group 2 was decreased from 225% with placebo to 128% with captopril (p < 0.02). The increase in sodium excretion after furosemide was decreased from 623% with placebo to 242% with captopril (p < 0.001). Pretreatment with captopril abolished the increase in creatinine clearance after furosemide. The increase in urinary albumin excretion (used as a marker of glomerular function) after furosemide was also significantly blunted by captopril. Conventional doses of captopril acutely inhibit the natriuretic and diuretic responses to furosemide at the glomerular level in ambulant patients with stable chronic heart failure.

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