Acute respiratory effects of particles: mass or number?

T. Osunsanya, Gordon James Prescott, Anthony Seaton

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Objectives-To determine whether associations might be found, in patients with chronic airflow obstruction, between symptoms, peak flow rate (PEF), and particle mass and numbers, and to assess which measure was most closely associated with changes in health. Epidemiological studies have shown associations between particulate air pollution and cardiovascular and respiratory disease, and if has been proposed that these may be mediated by particles of nm size (ultrafine).

Methods-Relations were investigated between symptom scores, PEF, and bronchodilator use in 44 patients aged greater than or equal to 50 years with chronic obstructive pulmonary disease, and daily measurements of both mass of ambient particles of aerodynamic diameter less than 10 mum (PM10) and numbers of ultrafine particles (<100 nm), allowing for meteorological variables. Symptom scores, bronchodilator use, and PEF were recorded daily for 3 months. Counts of ultrafine particles were made by the TSI model 3934 scanning mobility particle sizer (SMPS) and PM10 measurements by the tapered element oscillating microbalance (TEOM).

Results-Ultrafine particle counts indoors and outdoors were significantly correlated, those indoors being about half of those outdoors. No associations were found between actual PEF and PM10 or ultrafine particles. However, there was a 19% increase in the rate of 10% decrements in daytime PEF with increases in PM10 from 10 to 20 <mu>g/m(3) which was of borderline significance (p=0.05). A change in PM10 from 10 to 20 mug/m(3) was significantly associated with a 14% increase in the rate of high scores of shortness of breath (p=0.003). A similar change in PM10 as a moving average of the same day and 2 previous days was associated with a 31% increase in the rate of high scores for cough (p=0.02). Cough symptoms were also associated with lower temperatures (p=0.02). Higher use of medicines was also associated with higher PM10, but the increases were very small in clinical terms.

Conclusions-Evidence was not found to support the hypothesis that the component of particulate pollution responsible for effects on respiratory symptoms or function resides in the fraction below 100 nm diameter. The consistent associations between symptoms. and PM10 suggest that a contribution of the coarser fraction should not be dismissed. Further studies will be needed before the conclusions of this specific project may be generalised.

Original languageEnglish
Pages (from-to)154-159
Number of pages5
JournalOccupational and Environmental Medicine
Volume58
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • air pollution
  • ultrafine particles
  • chronic obstructive lung disease
  • PARTICULATE AIR-POLLUTION
  • PEAK EXPIRATORY FLOW
  • ULTRAFINE PARTICLES
  • FINE PARTICLES
  • PM10 POLLUTION
  • HEALTH
  • CHILDREN
  • ASSOCIATION
  • SYMPTOMS

Cite this

Acute respiratory effects of particles: mass or number? / Osunsanya, T.; Prescott, Gordon James; Seaton, Anthony.

In: Occupational and Environmental Medicine, Vol. 58, No. 3, 2001, p. 154-159.

Research output: Contribution to journalArticle

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title = "Acute respiratory effects of particles: mass or number?",
abstract = "Objectives-To determine whether associations might be found, in patients with chronic airflow obstruction, between symptoms, peak flow rate (PEF), and particle mass and numbers, and to assess which measure was most closely associated with changes in health. Epidemiological studies have shown associations between particulate air pollution and cardiovascular and respiratory disease, and if has been proposed that these may be mediated by particles of nm size (ultrafine).Methods-Relations were investigated between symptom scores, PEF, and bronchodilator use in 44 patients aged greater than or equal to 50 years with chronic obstructive pulmonary disease, and daily measurements of both mass of ambient particles of aerodynamic diameter less than 10 mum (PM10) and numbers of ultrafine particles (<100 nm), allowing for meteorological variables. Symptom scores, bronchodilator use, and PEF were recorded daily for 3 months. Counts of ultrafine particles were made by the TSI model 3934 scanning mobility particle sizer (SMPS) and PM10 measurements by the tapered element oscillating microbalance (TEOM).Results-Ultrafine particle counts indoors and outdoors were significantly correlated, those indoors being about half of those outdoors. No associations were found between actual PEF and PM10 or ultrafine particles. However, there was a 19{\%} increase in the rate of 10{\%} decrements in daytime PEF with increases in PM10 from 10 to 20 g/m(3) which was of borderline significance (p=0.05). A change in PM10 from 10 to 20 mug/m(3) was significantly associated with a 14{\%} increase in the rate of high scores of shortness of breath (p=0.003). A similar change in PM10 as a moving average of the same day and 2 previous days was associated with a 31{\%} increase in the rate of high scores for cough (p=0.02). Cough symptoms were also associated with lower temperatures (p=0.02). Higher use of medicines was also associated with higher PM10, but the increases were very small in clinical terms.Conclusions-Evidence was not found to support the hypothesis that the component of particulate pollution responsible for effects on respiratory symptoms or function resides in the fraction below 100 nm diameter. The consistent associations between symptoms. and PM10 suggest that a contribution of the coarser fraction should not be dismissed. Further studies will be needed before the conclusions of this specific project may be generalised.",
keywords = "air pollution, ultrafine particles, chronic obstructive lung disease, PARTICULATE AIR-POLLUTION, PEAK EXPIRATORY FLOW, ULTRAFINE PARTICLES, FINE PARTICLES, PM10 POLLUTION, HEALTH, CHILDREN, ASSOCIATION, SYMPTOMS",
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TY - JOUR

T1 - Acute respiratory effects of particles: mass or number?

AU - Osunsanya, T.

AU - Prescott, Gordon James

AU - Seaton, Anthony

PY - 2001

Y1 - 2001

N2 - Objectives-To determine whether associations might be found, in patients with chronic airflow obstruction, between symptoms, peak flow rate (PEF), and particle mass and numbers, and to assess which measure was most closely associated with changes in health. Epidemiological studies have shown associations between particulate air pollution and cardiovascular and respiratory disease, and if has been proposed that these may be mediated by particles of nm size (ultrafine).Methods-Relations were investigated between symptom scores, PEF, and bronchodilator use in 44 patients aged greater than or equal to 50 years with chronic obstructive pulmonary disease, and daily measurements of both mass of ambient particles of aerodynamic diameter less than 10 mum (PM10) and numbers of ultrafine particles (<100 nm), allowing for meteorological variables. Symptom scores, bronchodilator use, and PEF were recorded daily for 3 months. Counts of ultrafine particles were made by the TSI model 3934 scanning mobility particle sizer (SMPS) and PM10 measurements by the tapered element oscillating microbalance (TEOM).Results-Ultrafine particle counts indoors and outdoors were significantly correlated, those indoors being about half of those outdoors. No associations were found between actual PEF and PM10 or ultrafine particles. However, there was a 19% increase in the rate of 10% decrements in daytime PEF with increases in PM10 from 10 to 20 g/m(3) which was of borderline significance (p=0.05). A change in PM10 from 10 to 20 mug/m(3) was significantly associated with a 14% increase in the rate of high scores of shortness of breath (p=0.003). A similar change in PM10 as a moving average of the same day and 2 previous days was associated with a 31% increase in the rate of high scores for cough (p=0.02). Cough symptoms were also associated with lower temperatures (p=0.02). Higher use of medicines was also associated with higher PM10, but the increases were very small in clinical terms.Conclusions-Evidence was not found to support the hypothesis that the component of particulate pollution responsible for effects on respiratory symptoms or function resides in the fraction below 100 nm diameter. The consistent associations between symptoms. and PM10 suggest that a contribution of the coarser fraction should not be dismissed. Further studies will be needed before the conclusions of this specific project may be generalised.

AB - Objectives-To determine whether associations might be found, in patients with chronic airflow obstruction, between symptoms, peak flow rate (PEF), and particle mass and numbers, and to assess which measure was most closely associated with changes in health. Epidemiological studies have shown associations between particulate air pollution and cardiovascular and respiratory disease, and if has been proposed that these may be mediated by particles of nm size (ultrafine).Methods-Relations were investigated between symptom scores, PEF, and bronchodilator use in 44 patients aged greater than or equal to 50 years with chronic obstructive pulmonary disease, and daily measurements of both mass of ambient particles of aerodynamic diameter less than 10 mum (PM10) and numbers of ultrafine particles (<100 nm), allowing for meteorological variables. Symptom scores, bronchodilator use, and PEF were recorded daily for 3 months. Counts of ultrafine particles were made by the TSI model 3934 scanning mobility particle sizer (SMPS) and PM10 measurements by the tapered element oscillating microbalance (TEOM).Results-Ultrafine particle counts indoors and outdoors were significantly correlated, those indoors being about half of those outdoors. No associations were found between actual PEF and PM10 or ultrafine particles. However, there was a 19% increase in the rate of 10% decrements in daytime PEF with increases in PM10 from 10 to 20 g/m(3) which was of borderline significance (p=0.05). A change in PM10 from 10 to 20 mug/m(3) was significantly associated with a 14% increase in the rate of high scores of shortness of breath (p=0.003). A similar change in PM10 as a moving average of the same day and 2 previous days was associated with a 31% increase in the rate of high scores for cough (p=0.02). Cough symptoms were also associated with lower temperatures (p=0.02). Higher use of medicines was also associated with higher PM10, but the increases were very small in clinical terms.Conclusions-Evidence was not found to support the hypothesis that the component of particulate pollution responsible for effects on respiratory symptoms or function resides in the fraction below 100 nm diameter. The consistent associations between symptoms. and PM10 suggest that a contribution of the coarser fraction should not be dismissed. Further studies will be needed before the conclusions of this specific project may be generalised.

KW - air pollution

KW - ultrafine particles

KW - chronic obstructive lung disease

KW - PARTICULATE AIR-POLLUTION

KW - PEAK EXPIRATORY FLOW

KW - ULTRAFINE PARTICLES

KW - FINE PARTICLES

KW - PM10 POLLUTION

KW - HEALTH

KW - CHILDREN

KW - ASSOCIATION

KW - SYMPTOMS

U2 - 10.1136/oem.58.3.154

DO - 10.1136/oem.58.3.154

M3 - Article

VL - 58

SP - 154

EP - 159

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 3

ER -