Abstract
Finnish Landrace sheep with a genetic lesion which results in restricted cysteine transport across the red cell membrane have total glutathione concentrations in their red blood cells that are approximately 40% of those in normal sheep of the same breed. However, dimethyldisulphide-challenged red blood cells from both phenotypes produce an ESR-spin adduct at similar rates. The resistance of the low glutathione phenotype red cells to oxidant challenge is reflected by increases in the activities of antioxidant enzymes. Sheep with a genotypic disorder in cysteine transport may be a suitable model for studying the genetic expression of antioxidant enzymes in response to oxidant loads.
Original language | English |
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Pages (from-to) | 177-181 |
Number of pages | 5 |
Journal | Free Radical Research Communications |
Volume | 18 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1993 |
Keywords
- glutathione
- antioxidants
- ESR
- sheep
- lipid-peroxidation
- free-radicals
- acid