Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action

Kendra Bence, Mirela Delibegovic, Gokhan Hotamisligil, Barbara Kahn, Benjamin Neel

Research output: Contribution to journalComment/debatepeer-review


The widespread use of Nestin-Cre mice has led to an increasing awareness of potential diet- and strain-dependent differences in body weight in these mice. Accordingly, we have tested the effect of Nestin-Cre alone in several strains of mice and have observed marked differences in body weight between Nestin-Cre and wild-type mice fed chow in some, but not all, strains (data not shown). Given these strain differences, and to rule out potential spurious results, we would like to add additional control data from experiments performed at the time of the original studies in our paper showing no effect of Nestin-Cre expression alone on body weight
Original languageEnglish
Number of pages1
JournalNature Medicine
Issue number237
Publication statusPublished - 2010


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