Adult height and head and neck cancer

a pooled analysis within the INHANCE Consortium

Emanuele Leoncini, Walter Ricciardi, Gabriella Cadoni, Dario Arzani, Livia Petrelli, Gaetano Paludetti, Paul Brennan, Daniele Luce, Isabelle Stucker, Keitaro Matsuo, Renato Talamini, Carlo La Vecchia, Andrew F Olshan, Deborah M Winn, Rolando Herrero, Silvia Franceschi, Xavier Castellsague, Joshua Muscat, Hal Morgenstern, Zuo-Feng Zhang & 41 others Fabio Levi, Luigino Dal Maso, Karl Kelsey, Michael McClean, Thomas L Vaughan, Philip Lazarus, Mark P Purdue, Richard B Hayes, Chu Chen, Stephen M Schwartz, Oxana Shangina, Sergio Koifman, Wolfgang Ahrens, Elena Matos, Pagona Lagiou, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Leticia Fernandez, Ana Menezes, Antonio Agudo, Alexander W Daudt, Lorenzo Richiardi, Kristina Kjaerheim, Dana Mates, Jaroslav Betka, Guo-Pei Yu, Stimson Schantz, Lorenzo Simonato, Hermann Brenner, David I Conway, Tatiana MacFarlane, Peter Thomson, Eleonora Fabianova, Ariana Znaor, Peter Rudnai, Claire Healy, Paolo Boffetta, Shu-Chun Chuang, Yuan-Chin Amy Lee, Mia Hashibe, Stefania Boccia

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Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Original languageEnglish
Pages (from-to)35-48
Number of pages14
JournalEuropean Journal of Epidemiology
Volume29
Issue number1
Early online date24 Nov 2013
DOIs
Publication statusPublished - Jan 2014

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Head and Neck Neoplasms
Odds Ratio
Confidence Intervals
Smoking
Mouth Neoplasms
Tobacco Use
Pharynx
Energy Intake
Alcohol Drinking
Case-Control Studies
Epidemiologic Studies
Epidemiology
Incidence
Neoplasms

Keywords

  • Adult
  • Aged
  • Alcohol Drinking
  • Body Height
  • Case-Control Studies
  • Educational Status
  • Female
  • Head and Neck Neoplasms
  • Humans
  • Incidence
  • Interviews as Topic
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Overweight
  • Risk Factors
  • Smoking
  • Cancer
  • Height
  • Consortium

Cite this

Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., ... Boccia, S. (2014). Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium. European Journal of Epidemiology, 29(1), 35-48. https://doi.org/10.1007/s10654-013-9863-2

Adult height and head and neck cancer : a pooled analysis within the INHANCE Consortium. / Leoncini, Emanuele; Ricciardi, Walter; Cadoni, Gabriella; Arzani, Dario; Petrelli, Livia; Paludetti, Gaetano; Brennan, Paul; Luce, Daniele; Stucker, Isabelle; Matsuo, Keitaro; Talamini, Renato; La Vecchia, Carlo; Olshan, Andrew F; Winn, Deborah M; Herrero, Rolando; Franceschi, Silvia; Castellsague, Xavier; Muscat, Joshua; Morgenstern, Hal; Zhang, Zuo-Feng; Levi, Fabio; Dal Maso, Luigino; Kelsey, Karl; McClean, Michael; Vaughan, Thomas L; Lazarus, Philip; Purdue, Mark P; Hayes, Richard B; Chen, Chu; Schwartz, Stephen M; Shangina, Oxana; Koifman, Sergio; Ahrens, Wolfgang; Matos, Elena; Lagiou, Pagona; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Fernandez, Leticia; Menezes, Ana; Agudo, Antonio; Daudt, Alexander W; Richiardi, Lorenzo; Kjaerheim, Kristina; Mates, Dana; Betka, Jaroslav; Yu, Guo-Pei; Schantz, Stimson; Simonato, Lorenzo; Brenner, Hermann; Conway, David I; MacFarlane, Tatiana; Thomson, Peter; Fabianova, Eleonora; Znaor, Ariana; Rudnai, Peter; Healy, Claire; Boffetta, Paolo; Chuang, Shu-Chun; Lee, Yuan-Chin Amy; Hashibe, Mia; Boccia, Stefania.

In: European Journal of Epidemiology, Vol. 29, No. 1, 01.2014, p. 35-48.

Research output: Contribution to journalArticle

Leoncini, E, Ricciardi, W, Cadoni, G, Arzani, D, Petrelli, L, Paludetti, G, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, AF, Winn, DM, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z-F, Levi, F, Dal Maso, L, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Purdue, MP, Hayes, RB, Chen, C, Schwartz, SM, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia-Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, AW, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G-P, Schantz, S, Simonato, L, Brenner, H, Conway, DI, MacFarlane, T, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S-C, Lee, Y-CA, Hashibe, M & Boccia, S 2014, 'Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium', European Journal of Epidemiology, vol. 29, no. 1, pp. 35-48. https://doi.org/10.1007/s10654-013-9863-2
Leoncini, Emanuele ; Ricciardi, Walter ; Cadoni, Gabriella ; Arzani, Dario ; Petrelli, Livia ; Paludetti, Gaetano ; Brennan, Paul ; Luce, Daniele ; Stucker, Isabelle ; Matsuo, Keitaro ; Talamini, Renato ; La Vecchia, Carlo ; Olshan, Andrew F ; Winn, Deborah M ; Herrero, Rolando ; Franceschi, Silvia ; Castellsague, Xavier ; Muscat, Joshua ; Morgenstern, Hal ; Zhang, Zuo-Feng ; Levi, Fabio ; Dal Maso, Luigino ; Kelsey, Karl ; McClean, Michael ; Vaughan, Thomas L ; Lazarus, Philip ; Purdue, Mark P ; Hayes, Richard B ; Chen, Chu ; Schwartz, Stephen M ; Shangina, Oxana ; Koifman, Sergio ; Ahrens, Wolfgang ; Matos, Elena ; Lagiou, Pagona ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Fernandez, Leticia ; Menezes, Ana ; Agudo, Antonio ; Daudt, Alexander W ; Richiardi, Lorenzo ; Kjaerheim, Kristina ; Mates, Dana ; Betka, Jaroslav ; Yu, Guo-Pei ; Schantz, Stimson ; Simonato, Lorenzo ; Brenner, Hermann ; Conway, David I ; MacFarlane, Tatiana ; Thomson, Peter ; Fabianova, Eleonora ; Znaor, Ariana ; Rudnai, Peter ; Healy, Claire ; Boffetta, Paolo ; Chuang, Shu-Chun ; Lee, Yuan-Chin Amy ; Hashibe, Mia ; Boccia, Stefania. / Adult height and head and neck cancer : a pooled analysis within the INHANCE Consortium. In: European Journal of Epidemiology. 2014 ; Vol. 29, No. 1. pp. 35-48.
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abstract = "Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95{\%} CI 0.86-0.95 for men; adjusted OR = 0.86, 95{\%} CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.",
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T2 - a pooled analysis within the INHANCE Consortium

AU - Leoncini, Emanuele

AU - Ricciardi, Walter

AU - Cadoni, Gabriella

AU - Arzani, Dario

AU - Petrelli, Livia

AU - Paludetti, Gaetano

AU - Brennan, Paul

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Matsuo, Keitaro

AU - Talamini, Renato

AU - La Vecchia, Carlo

AU - Olshan, Andrew F

AU - Winn, Deborah M

AU - Herrero, Rolando

AU - Franceschi, Silvia

AU - Castellsague, Xavier

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Zhang, Zuo-Feng

AU - Levi, Fabio

AU - Dal Maso, Luigino

AU - Kelsey, Karl

AU - McClean, Michael

AU - Vaughan, Thomas L

AU - Lazarus, Philip

AU - Purdue, Mark P

AU - Hayes, Richard B

AU - Chen, Chu

AU - Schwartz, Stephen M

AU - Shangina, Oxana

AU - Koifman, Sergio

AU - Ahrens, Wolfgang

AU - Matos, Elena

AU - Lagiou, Pagona

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Fernandez, Leticia

AU - Menezes, Ana

AU - Agudo, Antonio

AU - Daudt, Alexander W

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Mates, Dana

AU - Betka, Jaroslav

AU - Yu, Guo-Pei

AU - Schantz, Stimson

AU - Simonato, Lorenzo

AU - Brenner, Hermann

AU - Conway, David I

AU - MacFarlane, Tatiana

AU - Thomson, Peter

AU - Fabianova, Eleonora

AU - Znaor, Ariana

AU - Rudnai, Peter

AU - Healy, Claire

AU - Boffetta, Paolo

AU - Chuang, Shu-Chun

AU - Lee, Yuan-Chin Amy

AU - Hashibe, Mia

AU - Boccia, Stefania

PY - 2014/1

Y1 - 2014/1

N2 - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

AB - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

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KW - Aged

KW - Alcohol Drinking

KW - Body Height

KW - Case-Control Studies

KW - Educational Status

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Incidence

KW - Interviews as Topic

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Overweight

KW - Risk Factors

KW - Smoking

KW - Cancer

KW - Height

KW - Consortium

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DO - 10.1007/s10654-013-9863-2

M3 - Article

VL - 29

SP - 35

EP - 48

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

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