Adult mastocytosis: an immunophenotypic and flow-cytometric investigation

Anthony Ormerod, Richard Herriot, R J Davidson, H F Sewell

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19 Citations (Scopus)

Abstract

Skin mast cells of five patients with mastocytosis/urticaria pigmentosa and from four normal controls were immunophenotyped with a panel of 17 monoclonal antibodies; peripheral blood mononuclear cells from the patients were similarly labelled and analysed by flow cytometry. Cutaneous mast cells expressed leucocyte common antigen and markers of macrophage/monocyte lineage suggesting a common progenitor in the ontogeny of the two cell types. The mast cells from the patients differed from the controls, expressing HLA-DR in four cases, and this may be a feature of proliferating cells. The patients' peripheral blood T lymphocytes showed a marked increase in the activation markers HLA-DR and CD25 suggesting a contributory role, possibly via cytokines, in driving mast-cell proliferation.
Original languageEnglish
Pages (from-to)737-744
Number of pages8
JournalBritish Journal of Dermatology
Volume122
Issue number6
DOIs
Publication statusPublished - 1 Jun 1990

Keywords

  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, CD45
  • Antigens, Differentiation
  • Biological Markers
  • Cell Division
  • Female
  • Flow Cytometry
  • HLA-DR Antigens
  • Histocompatibility Antigens
  • Humans
  • Immunohistochemistry
  • Leukocytes, Mononuclear
  • Lymphocyte Activation
  • Male
  • Mast Cells
  • Mastocytosis
  • Middle Aged
  • Phenotype
  • Skin
  • T-Lymphocytes

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