Abstract
Skin mast cells of five patients with mastocytosis/urticaria pigmentosa and from four normal controls were immunophenotyped with a panel of 17 monoclonal antibodies; peripheral blood mononuclear cells from the patients were similarly labelled and analysed by flow cytometry. Cutaneous mast cells expressed leucocyte common antigen and markers of macrophage/monocyte lineage suggesting a common progenitor in the ontogeny of the two cell types. The mast cells from the patients differed from the controls, expressing HLA-DR in four cases, and this may be a feature of proliferating cells. The patients' peripheral blood T lymphocytes showed a marked increase in the activation markers HLA-DR and CD25 suggesting a contributory role, possibly via cytokines, in driving mast-cell proliferation.
Original language | English |
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Pages (from-to) | 737-744 |
Number of pages | 8 |
Journal | British Journal of Dermatology |
Volume | 122 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 1990 |
Keywords
- Adult
- Aged
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, CD45
- Antigens, Differentiation
- Biological Markers
- Cell Division
- Female
- Flow Cytometry
- HLA-DR Antigens
- Histocompatibility Antigens
- Humans
- Immunohistochemistry
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Male
- Mast Cells
- Mastocytosis
- Middle Aged
- Phenotype
- Skin
- T-Lymphocytes