Advanced analytical methodologies to study the microbial metabolome of the human gut

Wendy R. Russell* (Corresponding Author), Sylvia H. Duncan

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalTrAC - Trends in Analytical Chemistry
Volume52
Early online date30 Sep 2013
DOIs
Publication statusPublished - Dec 2013

Fingerprint

diabetes
cardiovascular disease
cancer
metabolite
spectroscopy
protein
Dietary Proteins
methodology
Medical problems
Metabolites
Spectroscopy
Fibers
fibre

Keywords

  • Aromatic amino acid
  • Dietary fiber
  • Dietary protein
  • Gut health
  • Metabolomics
  • Metagenomics
  • Microbial metabolite
  • Microbiota
  • Short-chain fatty acid
  • Spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

@article{275b0d08169e4989800f4c943ad706c2,
title = "Advanced analytical methodologies to study the microbial metabolome of the human gut",
abstract = "Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.",
keywords = "Aromatic amino acid, Dietary fiber, Dietary protein, Gut health, Metabolomics, Metagenomics, Microbial metabolite, Microbiota, Short-chain fatty acid, Spectroscopy",
author = "Russell, {Wendy R.} and Duncan, {Sylvia H.}",
note = "Funding is gratefully acknowledged from the Scottish Government Rural and Environment Science and Analytical Services Division from the research program ‘Food Land and People’.",
year = "2013",
month = "12",
doi = "10.1016/j.trac.2013.08.004",
language = "English",
volume = "52",
pages = "54--60",
journal = "Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "Elsevier",

}

TY - JOUR

T1 - Advanced analytical methodologies to study the microbial metabolome of the human gut

AU - Russell, Wendy R.

AU - Duncan, Sylvia H.

N1 - Funding is gratefully acknowledged from the Scottish Government Rural and Environment Science and Analytical Services Division from the research program ‘Food Land and People’.

PY - 2013/12

Y1 - 2013/12

N2 - Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

AB - Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

KW - Aromatic amino acid

KW - Dietary fiber

KW - Dietary protein

KW - Gut health

KW - Metabolomics

KW - Metagenomics

KW - Microbial metabolite

KW - Microbiota

KW - Short-chain fatty acid

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84887620358&partnerID=8YFLogxK

U2 - 10.1016/j.trac.2013.08.004

DO - 10.1016/j.trac.2013.08.004

M3 - Review article

VL - 52

SP - 54

EP - 60

JO - Trends in Analytical Chemistry

JF - Trends in Analytical Chemistry

SN - 0165-9936

ER -