Advanced analytical methodologies to study the microbial metabolome of the human gut

Wendy R. Russell; Sylvia H. Duncan

doi:10.1016/j.trac.2013.08.004

Advanced analytical methodologies to study the microbial metabolome of the human gut

Wendy R. Russell^* (Corresponding Author), Sylvia H. Duncan

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

Original language	English
Pages (from-to)	54-60
Number of pages	7
Journal	TrAC - Trends in Analytical Chemistry
Volume	52
Early online date	30 Sep 2013
DOIs	https://doi.org/10.1016/j.trac.2013.08.004
Publication status	Published - Dec 2013

Keywords

Aromatic amino acid
Dietary fiber
Dietary protein
Gut health
Metabolomics
Metagenomics
Microbial metabolite
Microbiota
Short-chain fatty acid
Spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trac.2013.08.004Licence: Unspecified

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title = "Advanced analytical methodologies to study the microbial metabolome of the human gut",

abstract = "Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.",

keywords = "Aromatic amino acid, Dietary fiber, Dietary protein, Gut health, Metabolomics, Metagenomics, Microbial metabolite, Microbiota, Short-chain fatty acid, Spectroscopy",

author = "Russell, {Wendy R.} and Duncan, {Sylvia H.}",

note = "Funding is gratefully acknowledged from the Scottish Government Rural and Environment Science and Analytical Services Division from the research program {\textquoteleft}Food Land and People{\textquoteright}.",

year = "2013",

month = dec,

doi = "10.1016/j.trac.2013.08.004",

language = "English",

volume = "52",

pages = "54--60",

journal = "Trends in Analytical Chemistry",

issn = "0165-9936",

publisher = "Elsevier",

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TY - JOUR

T1 - Advanced analytical methodologies to study the microbial metabolome of the human gut

AU - Russell, Wendy R.

AU - Duncan, Sylvia H.

N1 - Funding is gratefully acknowledged from the Scottish Government Rural and Environment Science and Analytical Services Division from the research program ‘Food Land and People’.

PY - 2013/12

Y1 - 2013/12

N2 - Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

AB - Emerging evidence suggests that the gut microbiota play an important role in the development of many diseases, including diabetes, cardiovascular disease and cancer. Spectroscopy-based methodologies provide a central, vital tool for the characterization of gut metabolites. This review explores the use and the importance of these techniques to evaluate the microbial metabolome with a particular focus on microbial transformation of dietary protein and fiber.

KW - Aromatic amino acid

KW - Dietary fiber

KW - Dietary protein

KW - Gut health

KW - Metabolomics

KW - Metagenomics

KW - Microbial metabolite

KW - Microbiota

KW - Short-chain fatty acid

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84887620358&partnerID=8YFLogxK

U2 - 10.1016/j.trac.2013.08.004

DO - 10.1016/j.trac.2013.08.004

M3 - Review article

AN - SCOPUS:84887620358

VL - 52

SP - 54

EP - 60

JO - Trends in Analytical Chemistry

JF - Trends in Analytical Chemistry

SN - 0165-9936

ER -

Advanced analytical methodologies to study the microbial metabolome of the human gut

Abstract

Keywords

UN SDGs

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